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T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION]]>
T in Hypoxia Inducible Factor-1 alpha (HIF-1α) gene and the presence of severely resorbed edentulous mandibular ridges in a sample of the Egyptian population. MATERIALS AND METHODS: The study was conducted on 50 subjects divided into case and control groups according to the residual ridge height. Saliva was used as a convenient source of DNA in the dental clinic. PCR-Restriction Fragment Length Polymorphism was performed for genotyping. RESULTS: A statistically significant difference in the distribution of the TT genotype between both groups was present. There was also a difference in the distribution of the CC and CT genotypes but it wasn’t statistically significant. The T alleles were more abundant in the case group while the control group showed more frequency of the C allele with no statistical significance. CONCLUSIONS: This study concluded that the TT genotype of the 1772C>T polymorphism of HIF-1α gene is related to the presence of severely atrophied residual ridges. This SNP can be used as a marker to predict the future condition of the ridge using saliva samples. Further studies on larger scale are recommended.]]>
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0.05). Histological assessment showed restoration of periodontal ligament attachment and increased vascularity in the study group. CONCLUSIONS: Laser irradiation reduces external root resorption and ankylosis in delayed tooth replantation.]]>
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II: (depression group) 10 rats were exposed to chronic unpredictable stress (CUS) to induce depression, Group III: (fluoxetine group) 10 ratswere exposed to chronic unpredictable stress (CUS) to induce depression and at the same time they were orally supplied with 10 mg/kg/day offluoxetine. After 3 months, the mandibles were dissected out and prepared for histological analysis using light microscope, scanning electronmicroscope (SEM) and energy dispersive x-ray microanalysis (EDX).RESULTS: In the control group, the alveolar bone surface showed a regular and smooth outline. In the depression group, there was a significantdisturbance in the bone architecture. The bone surface showed an irregular outline with multiple osteoclasts lying in How ship's lacunae. Deeplystained incremental lines were also evident. In the fluoxetine group, the bone surface restored its regular outline with multiple osteoblasts andosteocytes. The bone showed incremental lines indicating bone formation.CONCLUSIONS: Depression can lead to bone loss and osteoporosis. Fluoxetine is an effective drug in enhancing the bone condition andrestoring the normal architecture of the alveolar bone.]]>
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