ORIGINAL_ARTICLE
THE EFFECTIVENESS OF MELATONIN IN REDUCING PAIN RESULTING FROM RADIATION INDUCED ORAL MUCOSITIS: A RANDOMIZED CLINICAL TRIAL
BACKGROUND: Oral mucositis is a common side effect of anticancer radiotherapy causing severe ulceration of the mucosal tissues. Recently, melatonin supplements have been proposed as a new therapeutic modality for oral mucositis due to its antioxidant effects, anti-inflammatory, and anti-cancer properties.OBJECTIVES: evaluation of the effectiveness of melatonin in reducing pain resulting from radiation induced oral mucositisMATERIALS AND METHODS: Forty patients were randomly assigned to receive either: conventional treatment of oral mucositis, or 20 mg melatonin treatment in combination with the conventional treatment before irradiation, and for six weeks. All patients were evaluated for pain resulting from oral mucositis at three and six weeks after the start of radiotherapy.RESULTS: Oral mucositis patients in the melatonin group have experienced significantly lower pain scores oral mucositis compared to the control group.CONCLUSION: Adjuvant melatonin reduced the pain of oral mucositis, and the amount of analgesics used for pain treatment.
https://adjalexu.journals.ekb.eg/article_144849_8cc63b445ed2659d1acd1e4added1d93.pdf
2021-04-01
1
5
10.21608/adjalexu.2021.144849
Melatonin
Oral mucositis
Radiotherapy
Hossam
Elsabbagh
hossam.hamdy@alexu.edu.eg
1
Instructor of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology department, Faculty of Dentistry, Alexandria University, Egypt.
LEAD_AUTHOR
Eglal
Moussa
2
Professor of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology department, Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Sabah
Mahmoud
sabahamm@gmail.com
3
Professor of Medical Biochemistry department, Faculty of Medicine, Alexandria University, Egypt.
AUTHOR
Rasha
Elsaka
4
Clinical Oncology and Nuclear Medicine department, Faculty of Medicine, Alexandria University, Egypt
AUTHOR
1.Epstein JB, Schubert MM. Managing pain in mucositis. Seminars in Oncology Nursing. 2004;20:30-7.
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13. Moslehi A, Taghizadeh-Ghehi M, Gholami K, Hadjibabaie M, Jahangard-Rafsanjani Z, Sarayani A, et al. N-acetyl cysteine for prevention of oral mucositis in hematopoietic SCT: a double-blind, randomized, placebo-controlled trial. Bone marrow transplantation. 2014;49:818-23.
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14. Hardeland R, Pandi-Perumal SR, Cardinali DP. Melatonin. The international journal of biochemistry & cell biology. 2006;38:313-6.
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15. Abdel Moneim AE, Ortiz F, Leonardo-Mendonca RC, Vergano-Villodres R, Guerrero-Martinez JA, Lopez LC, et al. Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats. Acta tropica. 2015;143:58-65.
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17. Marshall KA, Reiter RJ, Poeggeler B, Aruoma OI, Halliwell B. Evaluation of the antioxidant activity of melatonin in vitro. Free radical biology & medicine. 1996;21:307-15.
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18. Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS, Kumar KS. Melatonin and protection from whole-body irradiation: survival studies in mice. Mutation research. 1999;425:21-7.
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19. Abdel Moneim AE, Guerra-Librero A, Florido J, Shen YQ, Fernandez-Gil B, Acuna-Castroviejo D, et al. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int J Mol Sci. 2017;18.
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22. Wang YM, Jin BZ, Ai F, Duan CH, Lu YZ, Dong TF, et al. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol. 2012;69:1213-20.
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39
ORIGINAL_ARTICLE
EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY)
INTRODUCTION: The repair and replacement of injured or defective bone is a critical problem in orthopedic treatment. Bone defects in the maxillofacial region are considered a serious health problem. The correct restoration of architecture and function of tissues of this important anatomical region is mandatory. A variety of methods are employed for treating such defects, however, each of the strategies has its own drawbacks. Significant development has been achieved with combining bioceramics and biopolymers. Chitosan/ nano-Hydroxyapatite (CH/nHA) has recently emerged a new strategy for promoting bone regeneration and enhancement of bone healing and remodeling. This composite has increased cell adhesion, cell proliferation, mechanical strength, alkaline phosphatase activity, protein adsorption, type I collagen production as well as expression of other osteogenic differentiation markers.OBJECTIVES: The aim of the present study is to assess the effectiveness of using Chitosan/ nano-Hydroxyapatite composite on healing and regeneration of bony defects of the jaws radiograhicaly by the aid of Cone beam computed tomography.METHODOLOGY: This study was performed on 14 patients having bone defects in their maxilla or mandible due to cysts or tumors. Patients were divided into two groups; test group in which patients had removal of bone lesion leaving bone defects treated with Chitosan/nano-Hydroxyapatite, and control group in which bone defects were left to heal spontaneously. Bone defects were examined radiographically using Cone beam computed tomography.RESULTS: A significant increase in bone density in bone defects treated with Chitosan/nano-hydroxyapatite, as well as significant decrease in bone defect size.
https://adjalexu.journals.ekb.eg/article_144906_163264ffad4d42c60bfc562a3ac293b8.pdf
2021-04-01
6
14
10.21608/adjalexu.2021.144906
Chitosan
nano-hydroxyapatite
Bone defect
bone regeneration
Dina
Abd EL Hafez
dinamorsy57@yahoo.com
1
BDS, MS, Faculty of Dentistry, Alexandria University.
LEAD_AUTHOR
Tarek
Ali
2
Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University
AUTHOR
Adham
El Ashwah
3
Assistant Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University.
AUTHOR
1- Shakir M, Jolly R, Khan AA, Ahmed SS, Alam S, Rauf MA, et al. Resol based chitosan/nano-hydroxyapatite nanoensemble for effective bone tissue engineering. Carbohydr Polym 2018;179:317-27.
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2- Sandor GK, Lindlom TC, Clokie CM. Bone Regeneration of the Cranio- maxillofacial and Dento-alveolar Skeletons in the Framework of Tissue Engineering. Topics in Tissue Engineering 2003;7:1-46.
2
3- Alan S, Miller M, Signorino F. Maxillofacial Defects and the Use of Growth Factors. Oral Maxillofacial Surg Clin N Am 2017;29:75-88.
3
4- Sculean A, Stavropoulos A, Bosshardt DD. Self-regeneration capacity of intra-oral bone defects. J clinc periodontolo 2019;46:S21.
4
5- Venkatesan J, Kim S. Chitosan composites for Bone Tissue Engineering-An overview. Mar Drugs 2010;8:2252-66.
5
6- Sowmya S, Bumgardener JD, Chennazhi KP, Nair SV, Jayakumar R. Role of nanostructured biopolymers and bioceramics in enamel, dentin and periodontal tissue regeneration. Prog Polym Sci 2013;38:1748-72.
6
7- Rodríguez-Vázquez M, Vega-Ruiz B, Ramos-Zúñiga R, Saldaña-Koppel DA Q-OL. Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine. Biomed Res Int 2015;2015:821279.
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8- Chambers P, Dunne NJ. Emerging areas of bone repair materials: nucleic acid therapy and drug delivery. In: Bone Repair Biomaterials (Second edition). 2019. p. 411-46.
8
9- Mohd pu’ad NA., Koshy P, Abdullah H., Idris M., Lee T. Syntheses of hydroxyapatite from natural sources. Heliyon 2019;5: e01588.
9
10- Elieh-Ali-komi D, R Hamblin M. Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials. Int J Adv Res 2016;4:411-27.
10
11- Panos I, Acosta N, Heras A. New drug delivery systems based on chitosan. Curr Drug Discov Technol 2008;5:333-41.
11
12- Beck SC, Jiang T, Nair LS, Laurencin CT. Chitosan for bone and cartilage regenerative engineering. In Chitosan Based Biomaterials Vol. 2. Woodhead Publishing; 2017. pp. 33-72.
12
13- Ezoddini-Ardakani F, Navabazam A, Fatehi F, Danesh-Ardekani M, Khadem S, Rouhi G. Histologic evaluation of chitosan as an accelerator of bone regeneration in microdrilled rat tibias. Dent Res J (Isfahan) 2012;9:694-9.
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14- Rinaudo M. Chitin and chitosan: Properties and applications. Prog Polym Sci. 2006;31:603-32.
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15- Aoki H. Medical application of Hydroxyapatite. Ishiyaku Euro America 1994;13-74.
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16- Krishnamurithy G. A review on hydroxyapatite-based scaffolds as a poteintial bone graft substitute for bone tissue engineering applications. J Univ Malaya Med Centre 2013;16:22-7.
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17- Gao X, Song J, Ji P, Zhang X, Li X, Xu et al. Polydopamine-templated hydroxyapatite reinforced polycaprolactone composite nano fibers with enhanced cytocompatibility and osteogenesis for bone tissue engineering. Applied Materials & Interfaces 2016;8:3499-515.
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18- Murugan, R., & Ramakrishna S. Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite. Biomaterials 2004;25:3829-35.
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19- Wang H, Li Y, Zuo Y, Li J, Ma S, Cheng L. Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering. Biomaterials 2007;28:3338-48.
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20- Wang F, Zhang YC, Zhou H, Guo YC, Su XX. Evaluation of in vitro and in vivo osteogenic differentiation of nano-hydroxyapatite/ chitosan/ poly (lactide-co-glycolide) scaffolds with human umbilical cord mesenchymal stem cells. J Biomed Mater Res 2014;102:760-8.
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21- Cai B, Zou Q, Zuo Y, Li L, Yang B. Li Y. Fabrication and cell viability of injectable n-HA/chitosan composite microspheres for bone tissue engineering. Rsc Advances 2016;6:85735-44.
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22- Fan T, Chen J, Pan P, Zhang Y, Hua Y, Liu X, et al. Bioinspired double polysaccharides-based nanohybrid scaffold for bone tissue engineering. Colloids Surf B Biointerfaces 2016;147:217-223.
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23- Fang X, Xie J, Zhong L, Li J, Rong D, Li X. Biomimetic gelatin methacrylamide hydrogel scaffolds for bone tissue engineering. J Mater Chem 2016;4:1070-80.
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24- Escobar-Sierra DM, Martins J, Ossa-Orozco CP. Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison. Rev Fac Ing Univ Antioquia 2015;75:24-35.
24
25- Leonhardt A, Dahlen G, Renvert S. Five-year clinical, microbiological and radiological outcome following treatment of peri-implantitis in man. J Periodontol 2003;74:1415-22.
25
26- Patel R, Wilson R, Palmer R. The Effect of Smoking on Periodontal Bone Regeneration: A Systematic Review and Meta-Analysis. J Periodontol 2012;83:143-55.
26
27- Manfredini D, Poggio CE, Lobbezoo F. Is bruxism a risk factor for dental implants? A systemic review of the literature. Clin Implant Dent Relat Res 2012;16:460-9.
27
28- Estrela C, Bueno MR, Azevedo BC, Azevedo JR, Pécora JD. A New Periapical Index Based on Cone Beam Computed Tomography. J Endod 2008;34:1325-31.
28
29- Ellis E, Hupp J, Tucker M. Contemporary Oral and Maxillofacial surgery. 4th (ed). Philadelphia: Mobsy. 2002.
29
30- Newman M, Takei H, Carranza F. Carranza’s clinical periodontology. 9th (ed). Pjiladelphia: Saunders. 2001.
30
31- Haghighat A, Hekmatian E, Abdinian M, Sadeghkhani E. Radiographic evaluation of bone formation and density changes after mandibular third molar extraction: A 6 month follow up. Dent Res J (Isfahan) 2011;8:1-5.
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32- Smieszek-Wilczewska J, Koszowski R, Pajak J. Comparison of postoperation bone defects healing of alveolar processes of maxilla and mandible with the use of Bio-Gen and Bio-Oss. J Clin Exo Dent 2010;2:62-8.
32
33- Vaca-Cornejo F, Reyes HM, Jiménez SHD, Velázquez RAL, Jiménez JMD. Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis. J Funct Biomater 2017;8:e29.
33
34- Chatzipetros E, Yfanti Z, Christopoulos P, Donta C, Damaskos S, Tsiambas E, et al. Imaging of nano-hydroxyapatite/chitosan scaffolds using a cone beam computed tomograhydevice on rat calvarial defects with histological verification. Clin Oral Invest 2019;18:1–10.
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35- Huang Z, Chen Y, Feng QL, Zhao W, Yu B, Tian J, et al. In vivo bone regeneration with injectable chitosan/hydroxyapatite/collagen composites and mesenchymal stem cells. Front Mter Sci 2011;5:301-10.
35
36- Shenoy N, Ahmed J, Mallya SM. Add a third dimension to your patient care with cone beam computed tomography. J Interdiscip Dentistry 2014;4:118-22.
36
ORIGINAL_ARTICLE
CORTICAL TENTING TECHNIQUE FOR VERTICAL AUGMENTATION OF ATROPHIC POSTERIOR PART OF THE MANDIBLE (CLINICAL TRIAL)
INTRODUCTION: The progressive decrease in the alveolar bone volume after tooth loss impedes the use of dental implants for rehabilitation of edentulous regions. This fact is of utmost significance in the posterior areas of mandible, where the presence of inferior alveolar nerve further complicates the proper insertion of dental implants. Considering the drawbacks of the non-reconstructive treatment options, restoring deficits of alveolar ridges by reconstructive procedures might still be more practicable, despite the invasiveness. The majority of reconstructive techniques involve a process of bone grafting and vertical ridge augmentation. Cortical tenting technique is used for vertical ridge augmentation and can achieve a good degree of success.OBJECTIVES: To evaluate the effectiveness of cortical tenting technique in vertical ridge augmentation of atrophic posterior mandibles.METHODS: The study was made on ten patients with atrophic posterior part of the mandible. In each one of them, the atrophic alveolar ridge will be treated with cortical tenting technique. Bone height over the mandibular canal was measured on Standardized CBCT scans taken preoperatively (base line), and 1 week and 4 months postoperatively and bone density was measured at grafted area 4 months postoperatively.RESULTS: The average final bone gain was 4.540 mm at the end of follow up period with 1.700 mm average of graft resorption. Estimated bone density was measured also at grafted area 4 months after surgery with a mean value of 398.59 voxel value (VV).CONCLUSION: The use of cortical block graft taken from the ramus of the mandible to augment vertical bone defect in the posterior of the mandible has significant success rates.
https://adjalexu.journals.ekb.eg/article_144851_6b710ca3c26f65676594637b9696ef26.pdf
2021-04-01
15
22
10.21608/adjalexu.2021.144851
Vertical augmentation
Cortical tenting
Atrophic mandible
piezosurgery
John
Hares
john.kamal12@yahoo.com
1
BDS, 2014, Faculty of Dentistry, Alexandria University.
LEAD_AUTHOR
Sherif
Mohamed
2
Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Marwa
Noureldin
drmarwagamal23@gmail.com
3
Lecturer of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt
AUTHOR
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34. Wang X, Luo Y. Influencing factors on bone resorption after alveolar bone grafting. Zhonghua Kou Qiang Yi Xue Za Zhi 2005;40:373-5.
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35. Antoun H, Sitbon JM, Martinez H, Missika P. A prospective randomized study comparing two techniques of bone augmentation: onlay graft alone or associated with a membrane. Clin Oral Implants Res. 2001;12:632-9.
35
36. Chenchev IL, Ivanova VV, Neychev DZ, Cholakova RB. Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report. Folia Med (Plovdiv). 2017;59:362-6.
36
37. Alkhader M, Hudieb M, Khader Y. Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values. Eur J Dent. 2017;11:311-6.
37
38. Zhang J, Tian Y, Liu Y, Liu Q, Zhang J, Liu J, et al. Alveolar Bone Mineral Density Measurement using CBCT Images. Neuroscience and Biomedical Engineering. 2017;5(1):44-9.
38
39. Schultze-Mosgau S, Keweloh M, Wiltfang J, Kessler P, Neukam F. Histomorphometric and densitometric changes in bone volume and structure after avascular bone grafting in the extremely atrophic maxilla. British Journal of Oral and Maxillofacial Surgery. 2001;39(6):439-47.
39
40. Cassetta M, Stefanelli LV, Pacifici A, Pacifici L, Barbato E. How accurate Is CBCT in measuring bone density? A comparative CBCT‐CT in vitro study. Clinical implant dentistry and related research. 2014;16(4):471-8.
40
ORIGINAL_ARTICLE
ACCURACY OF TOOTH GUIDED IMMEDIATE IMPLANT PLACEMENT AT MOLAR REGION (CLINICAL TRIAL)
INTRODUCTION: The concept of immediate implant placement has become popular due to reduced trauma and reduced overall treatment time. Removal of molar teeth provides a challenging and intriguing dilemma due to multiple root morphology. In cases of extraction and immediate placement of implants in the molar region, removal of the inter-radicular septum should be avoided to attain initial implant stability at the time of placement, and prevent slipping of the implant into the extraction socket. Following this technique prevents the slippage of the implant and allows the implant to be guided into the inter-radicular septum.OBJECTIVES: To assess the accuracy of implant placement using the remaining roots of multi-radicular mandibular molars, evaluate bone density around implants and implant stability in fresh extracted site.MATERIALS AND METHODS: A prospective study was done on 10 patients with badly destructed mandibular molars. The technique of implant insertion consisted of a progressive preparation of the implant site using the anatomy of the root of the multi-radicular mandibular molars to be extracted as a reference and as an aid to engage the inter-radicular septum. Implant stability was evaluated using Osstell; Radiographic evaluation was done by Cone Beam Computed Tomography.RESULTS: Nine out of ten implants were functioning successfully along the evaluation period, while one implant failed 4 weeks after insertion and was removed. Clinically, implants stability was assessed using Osstell. All implants showed increase in ISQ value after 3 months. Radiographically, immediate postoperative CBCT was carried out which showed implants placed in ideal position. After 6 months, CBCT showed increase in bone density around implants compared to the immediate postoperative CBCT.CONCLUSIONS: Tooth guided immediate implant placement at molar region is a novel technique for easy and safe implant insertion.
https://adjalexu.journals.ekb.eg/article_144837_5afe76c1cb51a89551717db185638756.pdf
2021-04-01
23
28
10.21608/adjalexu.2021.144837
Guided surgery
Immediate placement
implants bed preparation
Abdelrhman
Abdelazim
abdosahry@gmail.com
1
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
LEAD_AUTHOR
Samraa
Elsheikh
drsamraaelsheikh@hotmail.com
2
Professor of Oral and Maxillofacial Surgery Alexandria University, Alexandria, Egypt.
AUTHOR
Hala
Ragab
dr.hala.r.r@hotmail.com
3
Assistant Professor of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
AUTHOR
1. Schulte W, Heimke G. The Tubinger immediate implant. Die Quintessenz. 1976;27:17-23.
1
2. Botticelli D, Renzi A, Lindhe J, Berglundh T.Implants in fresh extraction sockets: A prospective5-year follow-up clinical study. Clin Oral Implants Res. 2008;19:1226-32.
2
3. Schwartz-Arad D, Laviv A, Levin L. Survival of immediately provisionalized dental implants placed immediately into fresh extraction sockets. J Periodontol. 2007;78:219-23.
3
4. Chen ST, Wilson TG, Jr., Hammerle CH. Immediate or early placement of implants following tooth extraction: review of biologic basis, clinical procedures, and outcomes. Int J Oral Maxillofac Implants. 2004;19 Suppl:12-25.
4
5. Moy PK, Nishimura GH, Pozzi A, Danda AK. Single implants indorsalareas –Asystematic review. Eur J Oral Implantol. 2016;9(Suppl 1):S163-72.
5
6. Scarano A. Traditional postextractive implant site preparation compared with pre-extractive interradicular implant bed preparation in the mandibular molar region, using an ultrasonic device: A randomized pilot study. Int J Oral Maxillofac Implants. 2017;32:655–60.
6
7. Rodriguez-Tizcareño MH, Bravo-Flores C. Anatomically Guided Implant Site Preparation Technique at Molar Sites. Implant Dent. 2009;18:393–401.
7
8. Barone A, Toti P, Quaranta A, Derchi G, Covani U. The Clinical Outcomes of Immediate Versus Delayed Restoration Procedures on Immediate Implants: A Comparative Cohort Study for Single-Tooth Replacement. Clin Implant Dent Relat Res. 2015;17:1114-26.
8
9. Atieh MA, Payne AG, Duncan WJ, de Silva RK, Cullinan MP. Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: a systematic review and meta-analysis. Int J Oral Maxillofac Implants. 2010;25:401-15.
9
10. Peñarrocha M, Uribe R, Balaguer J. Immediate implants after extraction. A review of the current situation. Med Oral. 2004;9:234-42.
10
11. Tolstunov L. Dental implant success-failure analysis: a concept of implant vulnerability. Implant Dent. 2006;15:341-6.
11
12. Sotto-Maior BS, Rocha EP, de Almeida EO, Freitas-Júnior AC, Anchieta RB, Del Bel Cury AA. Influence of high insertion torque on implant placement: an anisotropic bone stress analysis. Braz Dent J. 2010;21:508-14.
12
13.Mahesh L, Kurtzman GM, Schwartz D, Shukla S. Residual roots as an anatomical guide for implant placement: case series with two-year follow-up. J Oral Implantol. 2016;42:285-8.
13
14. Joshi V, Suhag V, Gupta S. Multirooted tooth guided immediate implant placement in molar sites: A report of two cases. Int J Curr Res. 2017;9:44967-9.
14
15.Davarpanah M, Szmukler-Moncler S. Unconventional implant treatment: I. Implant placement in contact with ankylosed root fragments. A series of five case reports. Clin Oral Implants Res. 2009;20:851-6.
15
16.Valenzuela S, Olivares JM, Weiss N, Benadof D. Immediate implant placement by interradicular bone drilling before molar extraction: clinical case report with one-year follow-up. Case Rep Dent. 2018;2018:6412826.
16
17. Di Giacomo GA, Cury PR, de Araujo NS, Sendyk WR, Sendyk CL. Clinical application of stereolithographic surgical guides for implant placement: preliminary results. J Periodontol. 2005;76:503-7.
17
18.Rohra E, Mistry G, Joshi T, Khanvilkar U. Implant bed preparation for immediate implantation in molar region: An alternative approach. JDMS. 2017;16:48-50.
18
19.Rebele SF, Zuhr O, Hürzeler MB. Pre-extractive interradicular implant bed preparation: case presentations of a novel approach to immediate implant placement at multirooted molar sites. Int J Periodontics Restorative Dent. 2013;33:89-96.
19
20.Albrektsson T, Jansson T, Lekholm U. Osseointegrated dental implants. Dent Clin North Am. 1986;30:151-74.
20
21. Parithimarkalaignan S, Padmanabhan TV. Osseointegration: an update. J Indian Prosthodont Soc. 2013;13:2-6.
21
22.Douglass GL, Merin RL. The immediate dental implant. J Calif Dent Assoc. 2002;30:362-5,368-74.
22
23.Wagenberg BD, Ginsburg TR. Immediate implant placement on removal of the natural tooth: retrospective analysis of 1,081 implants. Compend Contin Educ Dent. 2001;22:399-404, 406, 408 passim; quiz 412.
23
24.Acocella A, Bertolai R, Sacco R. Modified insertion technique for immediate implant placement into fresh extraction socket in the first maxillary molar sites: a 3-year prospective study. Implant Dent. 2010;19:220-8.
24
25. Tarnow DP, Chu SJ. Human histologic verification of osseointegration of an immediate implant placed into a fresh extraction socket with excessive gap distance without primary flap closure, graft, or membrane: a case report. Int J Periodontics Restorative Dent. 2011;31:515-21.
25
26. Schwartz‐Arad D, Chaushu G. The ways and wherefores of immediate placement of implants into fresh extraction sites: a literature review. Journal of periodontology. 1997 Oct 1;68(10):915-23.
26
ORIGINAL_ARTICLE
EVALUATION OF "TENT-POLE" GRAFTING TECHNIQUE FOR RECONSTRUCTION OF MANDIBULAR RIDGE VERTICAL DEFECTS (CLINICAL AND RADIOGRAPHIC STUDY)
regeneration after loss of the adequate bone height. Numerous techniques have been mentioned for reconstruction of the atrophic mandibular ridge. Tenting of the soft tissue matrix allow maintaining space for the graft material for vertical ridge augmentation.OBJECTIVES: The aim of this study is to evaluate clinically and radiographically the efficiency of "Tent- Pole" grafting using titanium mini-screws with guided bone regeneration for augmentation of mandibular ridge vertical defects.MATERIALS AND METHODS: Twelve patients with posterior mandibular defects were treated with guided bone regeneration around titanium screws that tent out the soft tissue matrix with an age range of 43 and 60 years. They were of both sexes (4 males and 8 females). Osteosynthesis mini-screws were fixed on the alveolar ridge with an average of 2-3 mm of their length exposed, alloplastic material surrounded the screws completely and a resorbable membrane is used for the guided bone regeneration.RESULTS: The mean bone height value after six months was found to be statistically significant with the mean bone height value preoperatively and immediate post operative (p < 0.001). Also, there was statistically significant difference in the mean bone density between the six months post operative and immediate post operative values (p < 0.001).CONCLUSION: From the results of this study, the screw tent -pole grafting technique with guided bone regeneration is a technique of high reliability in restoring mandibular vertical bone loss.
https://adjalexu.journals.ekb.eg/article_144845_6a026e147bc40b6b7bc30e7539129651.pdf
2021-04-01
29
35
10.21608/adjalexu.2021.144845
Tent-pole
guided bone regeneration (GBR)
Mandibular defect
Asmaa
Abd Elfattah
asmaa92m7amed@gmail.com
1
Oral and maxillofacial surgery ,Alexandria university,Egypt.
LEAD_AUTHOR
Abd El Aziz
Khalil
2
Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Lydia
Melek
lydia.nabil@gmail.com
3
Assistant professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
1. Carlsson L, Röstlund T, Albrektsson B, Albrektsson T, Brånemark PI. Osseointegration of titanium implants. Acta Orthop Scand. 1986;57:285-9.
1
2. Chiapasco M, Zaniboni M, Boisco M. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res. 2006;17:136-59.
2
3. Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol. 2008;35:203-15.
3
4. Draenert FG, Huetzen D, Neff A, Mueller WE. Vertical bone augmentation procedures: Basics and techniques in dental implantology. J Biomed Mater Res A. 2013; 102:1605-13.
4
5. Le B, Rohrer MD, Prasad HS. Screw “tent-pole” grafting technique for reconstruction of large vertical alveolar ridge defects using human mineralized allograft for implant site preparation. J Oral Maxillofac Surg. 2010;68:428-35.
5
6. Gomes KU, Carlini JL, Biron C, Rapoport A, Dedivitis RA. Use of allogeneic bone graft in maxillary reconstruction for installation of dental implants. J Oral Maxillofac Surg.2008;66:2335-8.
6
7. Gerike W, Bienengräber V, Henkel KO, Bayerlein T, Proff P, Gedrange T, et al. The manufacture of synthetic non-sintered and degradable bone grafting substitutes. Folia Morphol (Warsz). 2006;65:54-5.
7
8. Shivashankar VY, Johns DA, Vidyanath S, Sam G. Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion. J Conserv Dent. 2013;16:261-4.
8
9. Del Corso M, Toffler M, Dohan Ehrenfest DM. Use of an autologous leukocyte and platelet-rich fibrin (L-PRF) membrane in post-avulsion sites: an overview of Choukroun’s PRF. J Implant Adv Clin Dent. 2010;1:27-35.
9
10. Simion M, Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent. 1994;14:496-511.
10
11. Lindfors LT, Tervonen EA, Sándor GK, Ylikontiola LP. Guided bone regeneration using a titanium-reinforced ePTFE membrane and particulate autogenous bone: the effect of smoking and membrane exposure. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:825-30.
11
12. Abd El Raouf M, Kobayashi MF, AbdEl-Aal ABM, Zhang Y, Miron RJ. Novel Bioabsorbable Bovine Derived Atelo-Collagen Type I Membrane: characterization into Host Tissues. Periodon Prosthodon. 2017;3:1-6.
12
13.Kirkpatrick LA, Feeney BC. A simple guide to IBM SPSS: for version 20.0. 12th ed. USA. Wadsworth cengage learning; 2012 .
13
14. Porter JA, Von Fraunhofer JA. Success or failure of dental implants? A literature review with treatment considerations. Gen Dent. 2005;53:423-32; quiz 433, 446.
14
15. Good M, Stiller C, Zauszniewski JA, Anderson GC, Stanton-Hicks M, Grass JA. Sensation and distress of pain scales: reliability, validity, and sensitivity. J Nurs Meas.2001;9:219-38.
15
16. Seidel HM BJ, Dains JE, Benedict GW. Heart and blood vessels. In: Schrefer S (ed). Mosby’s Guide to Physical
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Examination. 3P
17
P ed. St. Louis: Mosby; 1995.
18
17. Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012;23:1-21.
19
18. Levin L, Schwartz-Arad D. The Effect of Cigarette Smoking on Dental Implants and Related Surgery. Implant Dent. 2005;14:357-61.
20
19. D’Souza D. Residual Ridge Resorption – Revisited. In: Virdi M (ed). Oral Health Care - Prosthodontics, Periodontology, Biology, Research and Systemic Conditions. Intech; 2012. P. 953-78. Available at: https://www.intechopen.com
21
20. Cassetta M, Sofan AA, Altieri F, Barbato E. Evaluation of alveolar cortical bone thickness and density for orthodontic mini-implant placement. J Clin Exp Dent. 2013;5:e245-52.
22
21. Bornstein MM, Scarfe WC, Vaughn VM, Jacobs R. Cone beam computed tomography in implant dentistry: a systematic review focusing on guidelines, indications, and radiation dose risks. Int J Oral Maxillofac Implants. 2014;29:55-77 .
23
22. Pedroso LA, Garcia RR, Leles JL, Leles CR, Silva MA. Impact of cone-beam computed tomography on implant planning and on prediction of implant size. Braz Oral Res. 2014;28:46-53.
24
23. Chasioti E, Sayed M, Drew H. Novel techniques with the aid of a staged CBCT guided surgical protocol. Case Rep Dent 2015;2015:439706.
25
24. Le B, Burstein J, Sedghizadeh PP. Cortical tenting grafting technique in the severely atrophic alveolar ridge for implant site preparation. Implant Dent. 2008;17:40-50.
26
25. Louis PJ, Gutta R, Said-Al-Naief N, Bartolucci AA. Reconstruction of the maxilla and mandible with particulate bone graft and titanium mesh for implant placement. J Oral Maxillofac Surg. 2008;66:235-45.
27
26. Marx RE, Shellenberger T, Wimsatt J, Correa P. Severely resorbed mandible: Predictable reconstruction with soft tissue matrix expansion (tent pole) grafts. J Oral Maxillofac Surg. 2002;60:878-88.
28
27. Akoush YH, Hakam MM, Al farmawy MI. Evaluation of “Tent Pole” grafting technique for vertical alveolar ridge augmentation with the use of rhBMP-2. M.Sc. Thesis. Faculty of Dentistry, Cairo University. 2014.
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28. Hoexter DL. Bone regeneration graft materials. J Oral Implantol. 2002;28:290-4 .
30
29. Dietze S, Bayerlein T, Proff P, Hoffmann A, Gedrange T. The ultrastructure and processing properties of Straumann Bone Ceramic® and NanoBone®. Folia Morphol (Warsz). 2006;65:63-5.
31
30. Eldibany RM, Shokry MM.The effect of Nanobone® in combination with platelet rich fibrin on bone regeneration following enucleation of large mandibular cysts. Tanta Dent J. 2014;11:100-8.
32
31. Al Rayess AM, El Dibany MM, Melek LN. Clinical and radiographic study of healing of mandibular fractures using plasma rich fibrin membrane with miniplate fixation. Alex Dent J. 2018;43:41-7.
33
32. Dohle E, El Bagdadi K, Sader R, Choukroun J, James Kirkpatrick C, Ghanaati S. Platelet-rich fibrin-based matrices to improve angiogenesis in an in vitro co-culture model for bone tissue engineering. J Tissue Eng Regen Med. 2018;12:598-610.
34
33. Dahlin C, Gottlow J, Linde A, Nyman S. Healing of maxillary and mandibular bone defects using a membrane technique. An experimental study in monkeys. Scand J Plast Reconstr Surg Hand Surg. 1990;24:13-9.
35
34. Urban IA, Nagursky H, Lozada JL. Hori-zontal ridge augmentation with a re-sorbable membrane and particulated autogenous bone with or without anor-ganic bovine bone-derived mineral: A prospective case series in 22 patients. Int J Oral Maxillofac Implants. 2011;26:404-14.
36
35. Simion M, Fontana F, Rasperini G, Maiorana C. Vertical ridge augmentation by expanded-polytetrafluoroethylene membrane and a combination of intraoral autogenous bone graft and deproteinized anorganic bovine bone (BioOss). Clin Oral Implants Res. 2007;18:620-9.
37
36. Yang JW, Park HJ, Yoo KH, Chung K, Jung S, Oh HK, et al. A comparison study between periosteum and resorbable collagen membrane on iliac block bone graft resorption in the rabbit calvarium. Head Face Med 2014;10:15.
38
37. Schmid J, Wallkamm B, Hämmerle CH, Gogolewski S, Lang NP. The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implants Res.1997;8:244-8.
39
38. Delloye C, Simon P, Nyssen-Behets C, Banse X, Bresler F, Schmitt D. Perforations of cortical bone allografts improve their incorporation. Clin Orthop Relat Res. 2002;396:240-7.
40
39. Slotte C, Lundgren D. Impact of cortical perforations of contiguous donor bone in a guided bone augmentation procedure: an experimental study in the rabbit skull. Clin Implant Dent Relat Res. 2002;4:1-10.
41
40. Barbosa DZ, de Assis WF, Shirato FB, Moura CC, Silva CJ, Dechichi P. Autogenous bone graft with or without perforation of the receptor bed: histologic study in rabbit calvaria. Int J Oral Maxillofac Implants. 2009;24:463-8.
42
ORIGINAL_ARTICLE
COMPARISON BETWEEN THE LINGUALLY BASED AND THE BUCCALLY BASED TRIANGULAR FLAP DESIGN IN THE SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS (CLINICAL TRIAL)
INTRODUCTION: Removal of wisdom teeth could be challenging owning to limited accessibility, the tooth’s structural location and probable nerve damage especially to the inferior alveolar nerve and the lingual nerve.OBJECTIVES: The primary goal of this study is to make a comparison between the lingually based triangular flap and the buccally based triangular flap in terms of post-operative healing and complications.METHODS: 20 patients between the age of 21 and 30 years were randomly selected for mandibular third molar removal from clinic of the Oral and Maxillofacial Department, Faculty of Dentistry, Alexandria University. They were divided into two groups the study group (n=10) was operated using the lingually based triangular flap design and the control group (n=10) was operated using the buccally based triangular flap design. The patients were recalled on the 2nd, 7th and 14th days postoperatively in order to evaluate postoperative pain ,swelling ,wound dehiscence , the incidence of dry socket formation and lingual nerve injury.RESULTS: The lingually based triangular flap showed inferior levels of pain and was statistically significant in the 3rd and 7th day postoperatively . The lingually based triangular flap design showed less amount of facial swelling and lower incidence of wound dehiscence, dry socket formation and lingual nerve injury but the difference between the groups was all statistically insignificant.CONCLUSION: Lingually based triangular flap design revealed better postoperative healing than buccally based triangular flap design.
https://adjalexu.journals.ekb.eg/article_144852_e7ccc7676023e4e997389d13770d15d1.pdf
2021-04-01
36
42
10.21608/adjalexu.2021.144852
Lingual Triangular Flap
Buccal Triangular
Impaction
mandibular molar
Nesma
Said
nesma.riham@yahoo.com
1
Oral and Maxillofacial Surgery department ,faculty of dentistry,Alexandria university
LEAD_AUTHOR
Saeeda
Osman
2
Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Ahmed
Sweedan
drahmed.sweedan@gmail.com
3
Lecturer of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
1.Lopes V, Mumenya R, Feinmann C, Harris M. Third molar surgery: an audit of the indications for surgery, post-operative complaints and patient satisfaction. Br J Oral Maxillofac Surg.1995;33:33-5.
1
2. Shevel E, Koepp WG, Bütow KW. A subjective assessment of pain and swelling following the surgical removal of impacted third molar teeth using different surgical techniques. SADJ. 2001;56:238-41.
2
3.Bello SA, Adeyemo WL, Bamgbose BO, Obi EV, Adeyinka AA. Effect of age, impaction types and operative time on inflammatory tissue reactions following lower third molar surgery. Head Face Med. 2011;28:7-8.
3
4.Amin MM, Laskin DM. Prophylactic use of third molars indomethacin for prevention of postsurgical complications after removal of impacted third molars. Oral Surg Oral Med Oral Pathol. 1983;55:448-51.
4
5. Sortino F, Cicciu M. Strategies used to inhibit postoperative swelling following removal of impacted lower third molar. Dent Res J (Isfahan). 2011;8:162-71.
5
6.Kirk DG, Liston PN, Tong DC, Love RM. Influence of two different flap designs on incidence of pain, swelling, trismus, and alveolar osteitis in the week following third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e1-6.
6
7. Suarez-Cunqueiro MM, Gutwald R, Reichman J, Otero- Cepeda XS, Schmelzeisen R, Compostela S. Marginal flap versus paramarginal flap in impacted third molar surgery: a prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:403-8.
7
8.Roode GJ, Butow K. An alternative surgical flap design for impacted third molars: a comparison of two different surgical techniques. SADJ. 2010,65: 246,248-51.
8
9.Briguglio F, Zenobio EG, Isola G, Briguglio R, Briguglio E, Farronato D, et al. Complications in surgical removal of impacted mandibular third molars in relation to flap design: clinical and statistical evaluations. Quintessence Int. 2011;42:445-53.
9
10.Yolcu Ü, Acar AH. Comparison of a new flap design with the routinely used triangular flap design in third molar surgery. Int J Oral Maxillofac Surg. 2015;44:1390-7.
10
11.Baqain ZH, Al-Shafi A, Hamdan A, Sawair A. Flap design and mandibular third molar surgery: a split mouth randomized clinical study. Int J Oral Maxillofac Surg. 2012;41:1020-4.
11
12.Ryabko BY, Stognienko VS, Shokin YI. A new test for randomness and its application to some cryptographic problems. J Stat Plan Infer. 2004;123:365-76.
12
13.Koymen R, Ortakoğlu K, Okcu KM, Altuğ HA, Aydıntuğ YS. Wound closure by skin traction. Turk J Med Sci. 2002;32:179-81.
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14.Van Gool AV, Ten Bosch JJ, Boering G. Clinical consequences of complaints and complications after removal of the mandibular third molar. Int J Oral Surg. 1977;6:29-37.
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15.Azaz B, Shteyer A, Piamenta M. Radiographic and clinical manifestations of the impacted mandibular third molar. Int JOral Surg. 2017;5:153-60.
15
16.Monaco G, Daprile G, Tavernese L, Corinaldesi G, Marchetti C. Mandibular third molar removal in young patients: an evaluation of 2 different flap designs. J Oral Maxillofac Surg. 2009;67:15-21.
16
17.Seymour RA, Walton JG. Pain control after third molar surgery. Int J Oral Surg. 1984;13:457-85.
17
18.Erdogan O, Tatlı U, Ustun Y, Damlar I. Influence of two different flap designs on the sequelae of mandibular third molar surgery. Oral Maxillofac Surg. 2011;15:147-52.
18
19.Mangla M, Rajput L, Kumar A, Rathi V, Jain H, Kumar S. Lingual Triangular Flap vs Triangular Flap: A pilot study. Int J Oral Health Med Res. 2017;4:62-4.
19
20.Garcia AG, Sampedro FG, Rey JG, Torreira MG. Trismus and pain after removal of impacted lower third molars. J Oral Maxillofac Surg. 1997;55:1223-6.
20
21.Conard SM, Blakey GH, Shugars DA, Marciani RD, Phillips C, White RP. Patients’ perception of recovery
21
after third molar surgery. J Oral Maxillofac Surg. 2017;57:1288-94.
22
22.Dolanmaz D, Esen A, Isik K, Candirli C. Effect of 2 flap designs on postoperative pain and swelling after impacted third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:244-6.
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23.Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007;19:117-28.
24
24.Kumar B S, T S, M V, Raman U. To Compare Standard Incision and Comma Shaped Incision and Its Influence on Post–Operative Complications in Surgical Removal of Impacted Third Molars. J Clin Diagn Res. 2013;7:1514-8.
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25.Mansuri S, Mujeeb A, Hussain SA, Hussain MA. Mandibular third molar impactions in male adults: Relationship of Operative time and Types of impaction on inflammatory complications. J Int Oral Health. 2014;6:9-15.
26
26.Suarez-Cunqueiro MM, Gutwald R, Reichman J, Otero-Cepeda LS, Schmelzeisen R, de Compostela S. Marginal flap versus paramarginal flap in impacted third molar surgery: a prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003: 95: 403– 408.
27
27.Kirk DG, Liston PN, Tong DC, Love RM. Influence of two different flap designs on incidence of pain, swelling, trismus and alveolar osteitis in the week following third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007: 104: e1–e6
28
28.Al-Samman AA. Can Flap Design Affects Patient Morbidity Following Mandibular Third Molar Surgery? Smile Dent J. 2016;11:18-21.
29
29.Menziletoglu D, Guler A, Basturk F, Isik B, Erdur E. Comparison of two different flap designs for bilateral impacted mandibular third molar surgery. Journal of Stomatology, Oral and Maxillofacial Surgery. 2019.
30
ORIGINAL_ARTICLE
MACRO VERSUS MICRO THREAD DESIGN IMPLANT AND THEIR EFFECT ON THE STABILITY
Introduction:Dental implants are considered stable tools for replacing missing teeth, achieving long-term success rates above 90 percent, and their use in dental practice has become normal. One of the reasons to this success is the primary reliability of an implant. Implant design is one of the main factors that play a role in stability. Objectives: The purpose of this study was to compare the role of the Macro thread design and the Micro thread design on implant stability through the use of the Resonance Frequency Analysis (RFA). Materials and Methods: The study was carried out on 6 patients, each of these patients has missing teeth on each side of posterior area in the lower jaw. All the right sides received Micro thread design implant (dentium implant,) and the left side received Macro thread design implant (Megagen AnyRidge). After dental implants were placed in their sites, the stability was measured by using the Resonance Frequency Analysis (RFA) to assess the stability of the two types of implants at three times periods: At the time of placing the implant, 3 months and 6 months. Results: The mean implant Stability value for Group A was 70.57±5.74 immediately post-operatively, on the 3 month to 77.14±6.74 and reach 84.29±6.02 on the 6 month, for Group B was 63.29±6.58 immediately post-operatively, on the 3 month 70.57 ± 4.69 and on the 6 month 77.14±4.53. The mean bone density values for Group A at 3 months was 481.98± 51.78 and at 6th month was 504.28± 47.50, in Group B the 3 months was 439.54±70.49 and at 6th month was 463.83± 74.44. Conclusion: The Micro thread design implants shows higher stability than Macro thread design.
https://adjalexu.journals.ekb.eg/article_144843_11f973cef59958e1d24b53df34d30b9c.pdf
2021-04-01
43
50
10.21608/adjalexu.2021.144843
Osseo integration
Implant design
Dentium implant
Megagen AnyRidge
Resonance Frequency designs available Analysis
CBCT
Ahmed
Saleh
ahmedfouadali148@gmail.com
1
Oral and maxillofacial surgery, density, Alexandria university, Alexandria, Egypt
LEAD_AUTHOR
Ahmed
El- Mahallawy
2
Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Hala
Ragab
dr.hala.r.r@hotmail.com
3
Assistant Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Egypt.
AUTHOR
Gehrke S, da Silva U, Del Fabbro M. Does Implant Design Affect Implant Primary Stability? A Resonance Frequency Analysis–Based Randomized Split-Mouth Clinical Trial. J Oral Implantol. 2015;41:e281-e6.
1
Javed F, Ahmed H, Crespi R, Romanos G. Role of primary stability for successful osseointegration of dental implants: Factors of influence and evaluation. Interv Med Appl Sci. 2013;5:162-7.
2
Ryu H, Namgung C, Lee J, Lim Y. The influence of thread geometry on implant osseointegration under immediate loading: a literature review. J Adv Prosthodont. 2014;6:547-54.
3
McCullough J, Klokkevold P. The effect of implant macro-thread design on implant stability in the early post-operative period: a randomized, controlled pilot study. Clin Oral Implants Res. 2017;28:1218-26.
4
Chowdhary R, Halldin A, Jimbo R, Wennerberg A. Influence of Micro Threads Alteration on Osseointegration and Primary Stability of Implants: An FEA and In Vivo Analysis in Rabbits. Clin Implant Dent Relat Res. 2015;17:562-9.
5
Rathmell JP, Hill B. Wall and Melzack’s Textbook of Pain, 5th E-dition. Anesth Analg. 2006;102:1914.
6
Schnitman P, Shulman L. Recommendations of the consensus development conference on dental implants. J Am Dent Assoc. 1979;98:373-7.
7
Landry RG, Turnbull RS, Howley T. Effectiveness of benzydamyne HCl in the treatment of periodontal post-surgical patients. Res Clin Forums. 1988;10:105-18.
8
Sennerby L, Meredith N. Implant stability measurements using resonance frequency analysis: biological and biomechanical aspects and clinical implications. Periodontol 2000. 2008; 47:51-66.
9
Meredith N, Alleyne D, Cawley P. Quantitative determination of the stability of the implant-tissue interface using resonance frequency analysis. Clin Oral Implants Res. 1996;7:261-7.
10
Brisman DL. The effect of speed, pressure, and time on bone temperature during the drilling of implant sites. Int J Oral Maxillofac Implants. 1996;11:35-7.
11
Esposito M, Hirsch J, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants, (I). Success criteria and epidemiology. Eur J Oral Sci. 1998;106:527-51.
12
Gapski R, Wang H, Mascarenhas P, Lang N. Critical review of immediate implant loading. Clin Oral Implants Res. 2003;14:515-27.
13
Sakoh J, Wahlmann U, Stender E, Nat R, Al-Nawas B, Wagner W. Primary stability of a conical implant and a hybrid, cylindric screw-type implant in vitro. Int J Oral Maxillofac Implants. 2006;21:560-6.
14
Rozé J, Babu S, Saffarzadeh A, Gayet-Delacroix M, Hoornaert A, Layrolle P. Correlating implant stability to bone structure. Clin Oral Implants Res. 2009;20:1140-5.
15
Bornstein MM, Cionca N, Mombelli A. Systemic conditions and treatments as risks for implant therapy Int J Oral Maxillofac Implants. 2009;24:12-27.
16
Gomez-de Diego R, Mang-de la Rosa M, Romero-Perez M, Cutando-Soriano A, Lopez-Valverde-Centeno A. Indications and contraindications of dental implants in medically compromised patients: Update. Med Oral Patol Oral Cir Bucal. 2014;19:e483-9.
17
Naser AZ, Etemadi S, Rismanchian M, Sheikhi M, Tavakoli M. Comparison of Conventional and Standardized Bone Densitometry around Implants in Periapical Radiographs during a Three Months Period. Dent Res J (Isfahan). 2011;8:33-8
18
Sim CP, Lang NP. Factors influencing resonance frequency analysis assessed by Osstell™mentor during implant tissue integration: I. Instrument positioning, bone structure, implant length. Clin Oral Implants Res. 2010;21:598-604.
19
Kessler-Liechti G, Zix J, Mericske-Stern R. Stability measurements of 1-stage implants in the edentulous mandible by means of resonance frequency analysis. Int J Oral Maxillofac Implants. 2008;23:353-8.
20
Meredith N, Shagaldi F, Alleyne D, Sennerby L, Cawley P. The application of resonance frequency measurements to study the stability of titanium implants during healing in the rabbit tibia. Clin Oral Implants Res. 1997;8:234-43.
21
Jaramillo R, Santos R, Lázaro P, Romero M, Rios-Santos J, Bullón P, et al. Comparative analysis of 2 resonance frequency measurement devices: Osstell Mentor and Osstell ISQ. Implant Dent. 2014;23:351-6.
22
Orsini E, Giavaresi G, Trirè A, Ottani V, Salgar-ello S. Dental implant thread pitch and its influence on the osseointegration process: an in vivo comparison study. Int J Oral Maxillofac Implants. 2012;27:383-92.
23
Lan T, Du J, Pan C, Lee H, Chung W. Biomechanical analysis of alveolar bone stress around implants with different thread designs and pitches in the mandibular molar area. Clin Oral Investig. 2012;16:363-9.
24
Kong L, Liu BL, Hu KJ, Li DH. Song YL. Ma P, et al. Optimized thrend pitch design and stress analysis of the cylinder screwed dental implant. Hua Xi Kou Qiang Yi Xue Za Zhi. 2006:24:509-12.
25
Abuhussein H, Pagni G, Rebaudi A, Wang H. The effect of thread pattern upon implant osseointegration. Clin Oral Implants Res. 2010;21:129-36.
26
Gehrke SA, Marin GW. Biomechanical evaluation of dental implants with three different designs: Removal torque and resonance frequency analysis in rabbits. Ann Anat. 2015;199:30-5.
27
Sabeva E, Peev S, Miteva M, Georgieva M. The impact of the thread design compared to the impact of the surface topography on the primary stability of implants inserted into fresh pig ribs. Scr Sci Med Dent. 2017;3:60-4.
28
McCullough J, Klokkevold P. The effect of implant macro-thread design on implant stability in the early post-operative period: a randomized, controlled pilot study. Clin Oral Implants Res. 2017;28:1218-26.
29
ORIGINAL_ARTICLE
ULTRASOUND GUIDED CLOSED REDUCTION VERSUS OPEN REDUCTION OF ZYGOMATIC ARCH IN ZYGOMATICOMAXILLARY FRACTURES
Introduction: trauma of the zygomaticomaxillary complex (ZMC) has profound functional as well as aesthetic implications. Treatment of ZMC fractures remains one of the most controversial issues in maxillofacial trauma with regard to the classification, diagnosis, surgical approach and treatment.Precise management of the ZMC fractures needs accurate diagnosis, accessible exposure, and precise rigid fixation Objectives: To compare between ultrasound guided closed reduction and open reduction of zygomatic arch in cases of ZMC fracture. Materials and methods: This study was conducted on a sample of twenty patients who had fracture repair of ZMC. Ten of them (study group) were treated via direct peri-orbital approach with the use of intra-operative ultrasound to guide zygomatic arch reduction. While the other ten patients (control group) via coronal approach with open reduction of zygomatic arch. Postoperative patient evaluation was performed with specific attention paid towards zygomatic arch reduction, nerve function, wound healing, and postoperative ocular complications. Results: Radiographic follow up showed no statistical significant difference between normal side and reduced side of zygomatic arch which reflect satisfactory arch reduction among both groups. Conclusion: From the results of this study it was concluded that ultrasonography is an effective method for guiding zygomatic arch reduction with other minimal incisions in cases of ZMC fracture. On the other hand, coronal incisions have advantages of giving excellent access to ZMC fracture with direct reduction of zygomatic arch but with considerable disadvantages.
https://adjalexu.journals.ekb.eg/article_127964_87f1f255db1762a7487349c743912c4a.pdf
2021-04-01
51
57
10.21608/adjalexu.2020.22402.1039
ZMC fractures
Ultrasound guided reduction
Coronal incisions
Tasneem
Amer
tasneem.amer87@gmail.com
1
oral and maxillofacial surgery department, faculty of dentistry, Alexandria university ,Alexandria,Egypt.
LEAD_AUTHOR
Ahmed
sharara
sharara47@gmail.com
2
Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt
AUTHOR
Nevien
Mohamed
noovy60@hotmail.com
3
Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt
AUTHOR
Riham
El Dibany
riham.eldibany@hotmail.com
4
Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University
AUTHOR
mohamed
el shafei
mohamedeshafei@yahoo.com
5
Assistant professor of Diagnostic and Interventional Radiology, Department of Diagnostic and Interventional Radiology Faculty of medicine, Alexandria University, Egypt.
AUTHOR
Kovacs A, Ghahremani M: Minimization of zygomatic complex fracture treatment. Int J Oral Maxillofac Surg. 2001; 30: 380.
1
Zhang Q, Dong Y, Zu-Bing L, Zhao J: Coronal incision for treating zygomatic complex fractures. J Cranio Maxillofac Surg. 2006; 34:182.
2
Chen C: Endoscopic zygomatic fracture repair. Plast Reconst Surg. 1998; 5: 282.
3
Nkenke E, Benz M, Maier T, Wiltfang J, Holbach L, Kramer M. Relative en- and exophthalmometry in zygomatic
4
fractures comparing optical non-contact, non-ionizing 3D imaging to the Hertel instrument and computed
5
tomography. J Cranio Maxillofacial Surg. 2003; 31:362
6
Nkenke E, Benz M, Maier T, Wiltfang J, Holbach L, Kramer M, Gerd H, Neukam F: Hertel exophthalmometry
7
versus computed tomography and optical 3D imaging for the determination of the globe position in zygomatic
8
fractures. Int J Oral Maxillofac Surg. 2004; 33: 125.
9
El-Anwar MW, Elsheikh E, Sweed AH, Ezzeldin N. Electromyography assessment in zygomaticomaxillary
10
complex fractures. Oral and Maxillofacial Surgery 2015;19(4):375–9
11
Meslemani D, Kellman RM. Zygomaticomaxillary complex fractures. Arch Facial Plast Surg 2012;14:62–6
12
Tarabichi M. Transsinus reduction and one-point fixation of malar fractures. Arch Otolaryngol Head Neck
13
Surg 1994; 120: 620-5.
14
Soejima K, Sakurai H, Nozaki M, et al. Semi-closed reduction of tripod fractures of zygoma under intraoperative
15
assessment using ultrasonography. J Plast Reconstr Aesthet Surg 2009; 62: 499-505.
16
10.Choi KY, Ryu DW, Yang JD, Chung HY. Feasibility of 4-point fixation using the preauricular approach in a
17
zygomaticomaxillary complex fracture.J Craniofac Surg. 2013;24(2):557-62.
18
Ohjimi H, Taniguchi Y, Tanahashi S, Era K, Fukushima T. Accessing the Orbital Roof via an Eyelid Incision: The
19
Transpalpebral Approach. Skull base surgery. 2000;10(4):211-216.
20
El-Anwar M, Elsheikh E, Hussein A,Tantawy A, Abdelbaki Y. Transconjunctival versus subciliary approach to
21
the infraorbital margin for open reduction of zygomaticomaxillary complex fractures: a randomized feasibility
22
study. Oral Maxillofac Surg. 2017; 21:187–92.
23
Salgarelli AC, Bellini P, Landini B, Multinu A, Consolo U. A comparative study of different approaches in the
24
treatment of orbital trauma: an experience based on 274 cases. Oral Maxillofac Surg. 2010; 14:23-7.
25
Carvalho A C, Pereira C C, Queiroz T P, Magro-Filho O. Intraoral approach to zygomatic fracture: modified
26
technique for infraorbital rim fixation. J Craniofac Surg. 2012;23(2):537–538.
27
15. Manson P N, Clark N, Robertson B. Comprehensive management of pan-facial fractures. J Craniomaxillofac
28
Trauma. 1995;1(1):43–56.
29
Raschke G F, Rieger U M, Bader R D. et al. The zygomaticomaxillary complex fracture - an anthropometric
30
appraisal of surgical outcomes. J Craniomaxillofac Surg. 2013;41(4):331–337.
31
Gulicher D, Krimmel M, Reinert S: The role of intraoperative ultrasonography in zygomatic complex fracture
32
repair. Int J Oral Maxillofac Surg. 2006; 35: 224.
33
Heiland M, Schmelzle R, Hebecker A, Schulze D: Intraoperative 3D imaging of the facial skeleton using the
34
SIREMOBIL Iso-C3D. Dentomaxillofac Radiol. 2004; 33: 130.
35
Archer, W. H.: Fractures of the facial bones and their treatment. In: Archer, W. H. (ed.): Oral and maxillofacial
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surgery. Saunders, Philadelphia(1975) 1274.
37
Adeyemoa W, Akadirib O. A systematic review of the diagnostic role of ultrasonography in maxillofacial fractures.Int J
38
Oral Maxillofac Surg.2011;40(7): 655-61.
39
21.Rama K, Koteswara N, Leela G, Santosh V, Ranganath N, Vijaya U. Role of Ultrasonography in Oral and
40
Maxillofacial Surgery: A Review of Literature. J. Oral Maxillofac. Surg.2015;14(2):162-70.
41
22.Akizuki H, Yoshida H, Michi K.Ultrasonographic evaluation during reduction of zygomatic arch fractures.J
42
Craniomaxillofac Surg. 1990;18(6):263-6.
43
Ma F, Tang S. Zygomatic arch reduction and malarplasty with multiple osteotomies: its geometric considerations.
44
Aesthetic Plast Surg. 2014;38(6):1143-50.
45
Kirkpatrick LA, Feeney BC. A simple guide to IBM SPSS: for version 20.0. 12th ed. USA. Wadsworth cengage
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learning; 2012.
47
Johnson C. Measuring Pain. Visual Analog Scale Versus Numeric Pain Scale: What is the Difference? J Chiropr
48
Med. 2005;4(1):43-4.
49
26.van den Bergh B, Karagozoglu KH, Heymans MW, Forouzanfar T. Aetiology and incidence of maxillofacial
50
trauma in Amsterdam: a retrospective analysis of 579 patients. J Craniomaxillofac Surg. 2012;40(6):e165-9.
51
27. Salentijn EG, van den Bergh B, Forouzanfar T. A ten-year analysis of midfacial fractures. J Craniomaxillofac
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Surg. 2013;41(7):630-6.
53
28. Sakr K, Farag IA, Zeitoun IM. Review of 509 mandibular fractures treated at the University Hospital, Alexandria, Egypt. Br J Oral Maxillofac Surg. 2006;44(2):107-11.
54
29. Melek LN, Sharara AA. Retrospective study of maxillofacial trauma in Alexandria University: Analysis of 177 cases. Tanta Dent J. 2016;13(1):28.
55
30.Boffano P, Kommers SC, Karagozoglu KH, Forouzanfar T. Aetiology of maxillofacial fractures: a review of published studies during the last 30 years. Br J Oral Maxillofac Surg. 2014;52(10):901-6.
56
31.Vriens JP, Moos KF. Morbidity of the infraorbital nerve following orbitozygomatic complex fractures. J Craniomaxillofac Surg. 1995;23(6):363-8.
57
Benoliel R, Birenboim R, Regev E, Eliav E. Neurosensory changes in the infraorbital nerve following zygomatic fractures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(6):657-65.
58
Kumar VS, Rao NK, Mohan KR, Krishna L, Prasad BS, Ranganadh N, et al. Minimizing complications associated with coronal approach by application of various modifications in surgical technique for treating facial trauma: A prospective study. Natl J Maxillofac Surg. 2016;7(1):21-8.
59
Lew DH, Park BY, Lee HB, Lew JD. Simple fixation method for unstable zygomatic arch fracture using double Kirschner's wires. Plast Reconstr Surg. 1998;101(5):1351-4.
60
McCann PJ, Brocklebank LM, Ayoub AF. Assessment of zygomatico-orbital complex fractures using ultrasonography. Br J Oral Maxillofac Surg. 2000;38(5):5259.
61
Kurita M, Okazaki M, Ozaki M, Tanaka Y, Tsuji N, Takushima A, et al. Patient satisfaction after open reduction and internal fixation of zygomatic bone fractures. J Craniofac Surg. 2010;21(1):45-9.
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37. Cheon JS, Seo BN, Yang JY, Son KM. Clinical Follow-up on Sagittal Fracture at the Temporal Root of the Zygomatic Arch: Does It Need Open Reduction? Arch Plast Surg. 2013;40(5):546-52.
63
ORIGINAL_ARTICLE
PROSPECTIVE RANDOMIZED STUDY BETWEEN ARTHROCENTESIS AND OPERATIVE ARTHROSCOPY IN THE MANAGEMENT OF TEMPOROMANDIBULAR JOINT INTERNAL DERANGEMENT
Introduction: Temporomandibular disorders (TMDs) are common conditions and internal derangement is the most common among them. Different methods have been suggested for treatment , beginning with conservative approaches ending with surgery. Nowadays, arthrocentesis and arthroscopy have decreased the need of the more complex surgical procedures. Despite such advancements, there is deficiency in the literature regarding prospective, randomized, clinical studies supporting either both of them. In doing the necessary studies, and comparing the results, it will be essential to develop a standardized criteria for patient selection and treatment options that can be used by all investigators. Objectives: To compare between arthrocentesis and operative arthroscopy in the management of patients with internal derangement of temporomandibular joint stage II and III Wilkes. Materials and Methods: a prospective study was done on 40 patients with temporomandibular joint internal derangement and were divided into 2 groups, 20 patients were treated with arthrocentesis and 20 patients were treated with operative arthroscopy. Results: The pain score was significantly lower in operative arthroscopy. The mouth opening was significantly higher in the operative arthroscopy. Conclusions: Operative arthroscopy is better than arthrocentesis as regards the postoperative pain and mouth opening.
https://adjalexu.journals.ekb.eg/article_128033_32fce0c8e2de238b6cf84ceb59cb1d07.pdf
2021-04-01
58
65
10.21608/adjalexu.2020.25155.1051
TMJ
TMJ Arthroscopy
Arthroscopy
Arthrocentesis
internal derangement
Aly
Atteya
aly_atteya@hotmail.com
1
Maxillofacial and Plastic Surgery , Faculty of Dentistry , Alexandria University ,Alexandria , Egypt
LEAD_AUTHOR
Mohamed
Warda
mwarda56@gmail.com
2
Maxillofacial and Plastic Surgery , Faculty of Dentistry, Alexandria University , Alexandria, Egypt
AUTHOR
Mohamed
Fata
drfata@doctor.com
3
Maxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
AUTHOR
Ahmed
Medra
ahmed.medra@alexu.edu.eg
4
Maxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
AUTHOR
Florencio
Gil
fmonje@oralmaxilofacial.com
5
Oral and maxillofacial surgery , Faculty of Medicine, Extremadura University, Badajoz, Spain
AUTHOR
Zhang S, Liu X, Yang X, Yang C, Chen M, Haddad MS, et al. Temporomandibular joint disc repositioning using bone anchors: an immediate post surgical evaluation by Magnetic Resonance Imaging. . BMC Musculoskelet Disord 2010;11:262.
1
Greene CS, Marbach JJ. Epidemiologic studies of mandibular dysfunction: a critical review. J Prosthet Dent 1982;48:184-90.
2
Seifeldin SA, Elhayes KA. Soft versus hard occlusal splint therapy in the management of temporomandibular disorders (TMDs). Saudi Dent J 2015;27:208-14.
3
Dolwick MF, Katzberg RW, Helms CA. Internal derangements of the temporomandibular joint: fact or fiction? J Prosthet Dent 1983;49:415-8.
4
Gonzalez-Garcia R, Gil-Diez Usandizaga JL, Rodriguez-Campo FJ. Arthroscopic anatomy and lysis and lavage of the temporomandibular joint. Atlas Oral Maxillofac Surg Clin North Am 2011;19:131-44.
5
Wilkes CH. Internal derangements of the temporomandibular joint. Pathological variations. Arch Otolaryngol Head Neck Surg 1989;115:469-77.
6
Kiehn CL, Desprez JD. Meniscectomy for internal derangement of temporomandibular joint. Br J Plast Surg 1962;15:199-204.
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Farrar WB, McCarty WL Jr. The TMJ dilemma. J Ala Dent Assoc 1979;63:19-26.
8
Onishi M. [Arthroscopy of the temporomandibular joint (author's transl)]. Kokubyo Gakkai Zasshi 1975;42:207- 13.
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LaskinDM.Temporomandibulardisorders:thepast,present,andfuture.Odontology2007;95:10-5.
10
Laskin D. Surgical management of internal derangements. Temporomandibular disorders: an evidenced-based
11
approach to diagnosis and treatment Chicago: Quintessence Publishers 2006:469-81.
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Murakami KI, Iizuka T, Matsuki M, Ono T. Recapturing the persistent anteriorly displaced disk by mandibular manipulation after pumping and hydraulic pressure to the upper joint cavity of the temporomandibular joint. Cranio
13
1987;5:17-24.
14
Nitzan DW, Dolwick MF, Martinez GA. Temporomandibular joint arthrocentesis: a simplified treatment for
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severe, limited mouth opening. J Oral Maxillofac Surg 1991;49:1163-7.
16
Monje-Gil F, Nitzan D, Gonzalez-Garcia R. Temporomandibular joint arthrocentesis. Review of the
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literature. Med Oral Patol Oral Cir Bucal 2012;17: 575-81.
18
Celic R, Jerolimov V, Knezovic Zlataric D, Klaic B. Measurement of mandibular movements in patients with
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temporomandibular disorders and in asymptomatic subjects. Coll Antropol 2003;27:43-9.
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HuskissonEC.Measurementofpain.Lancet1974;2:1127-31.
21
Nitzan DW. Temporomandibular joint arthrocentesis: biologic basis and treatment outcome. In: Stegenga B, de
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Bont LGM, (eds). Management of Temporomandibular Joint Degenerative Diseases: Biologic Basis and
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Treatment Outcome. Basel: Birkhäuser Basel; 1996. pp.113-23.
24
McCain JP, de la Rua H, LeBlanc WG. Puncture technique and portals of entry for diagnostic and operative
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arthroscopy of the temporomandibular joint. Arthroscopy 1991;7:221-32.
26
Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria,
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examinations and specifications, critique. J Craniomandib Disord 1992;6:301-55.
28
Okeson J. Etiology and identification of functional disturbances in masticatory system. management of
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temporomandibular joint and occlusion 7th ed: Elsevier; 2013.
30
Al-Moraissi EA, Wolford LM, Ellis E, 3rd, Neff A. The hierarchy of different treatments for arthrogenous
31
temporomandibular disorders: A network meta-analysis of randomized clinical trials. J Craniomaxillofac Surg
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2020;48:9-23.
33
Ahmed N, Sidebottom A, O'Connor M, Kerr HL. Prospective outcome assessment of the therapeutic benefits of
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arthroscopy and arthrocentesis of the temporomandibular joint. Br J Oral Maxillofac Surg 2012;50:745-8.
35
Al-Moraissi EA. Arthroscopy versus arthrocentesis in the management of internal derangement of the
36
temporomandibular joint: a systematic review and meta-analysis. Int J Oral Maxillofac Surg 2015;44:104-12.
37
MurakamiK,HosakaH,MoriyaY,SegamiN,IizukaT.Short-termtreatmentoutcomestudyforthemanagement of temporomandibular joint closed lock. A comparison of arthrocentesis to nonsurgical therapy and arthroscopic
38
lysis and lavage. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:253-7.
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HobeichJBSZ,IsmailE,SadigWM,HokayemNE,AlmasK.Arthroscopyversusarthrocentesis.Aretrospective
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study of disc displacement management without reduction. Saudi Med J 2007;28:1541-4.
41
Fridrich KL, Wise JM, Zeitler DL. Prospective comparison of arthroscopy and arthrocentesis for
42
temporomandibular joint disorders. J Oral Maxillofac Surg 1996;54:816-20.
43
GoudotP,JaquinetAR,HugonnetS,HaefligerW,RichterM.Improvementofpainandfunctionafterarthroscopy
44
and arthrocentesis of the temporomandibular joint: a comparative study. J Craniomaxillofac Surg 2000;28:39-43.
45
XuY,LinH,ZhuP,ZhouW,HanY,ZhengY,etal.Acomparativestudybetweenuseofarthroscopiclavageand arthrocentesis of temporomandibular joint based on computational fluid dynamics analysis. PLoS One 2013;8:e78953.
46
Tan DBP, Krishnaswamy G. A Retrospective Study of Temporomandibular Joint Internal Derangement Treated with Arthrocentesis and Arthroscopy. Proceedings of Singapore Healthcare 2012;21:73-8.
47
Gonzalez-GarciaR,Rodriguez-CampoFJ,Escorial-HernandezV,Munoz-GuerraMF,Sastre-PerezJ,Naval-Gias L, et al. Complications of temporomandibular joint arthroscopy: a retrospective analytic study of 670 arthroscopic procedures. J Oral Maxillofac Surg 2006;64:1587-91.
48
ORIGINAL_ARTICLE
DENTAL STEM CELLS (CONCEPTS AND APPLICATIONS)
Stem cells constitute the source of differentiated cells for the generation of tissues during development, as well as for regeneration of tissues that are diseased or injured postnatally. The stem cell research has grown exponentially to improve the life of patients with conditions that span from Alzheimer’s disease, cardiac ischemia to bone or tooth loss. In dentistry, stem cell biology and tissue engineering are of great interest since they may provide an innovative for generation of clinical material and/or tissue regeneration. Mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, dental papilla, and dental follicle. These stem cells can be isolated and grown under defined tissue culture conditions and are potential cells for use in tissue engineering including dental tissue, nerves and bone regeneration under appropriate conditions. This review was performed to study the concepts of stem cells and the most recent application of dental stem cells.
https://adjalexu.journals.ekb.eg/article_88450_752a41083d98192a3ace3191f3d942f3.pdf
2021-04-01
66
71
10.21608/adjalexu.2020.88450
stem cells
Dental stem cells
Pluripotent
Multipotent
Ahmed
Hussein
ahmed.mohamed@dent.svu.edu.eg
1
Lecturer of Oral and Maxillofacial Pathology Department, Faculty of Oral and Dental Medicine, SVU, Qena, Egypt.
LEAD_AUTHOR
Zeinab
Darwish
2
Professor of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
AUTHOR
Hanaa
Raslan
hanaaraslan@hotmail.com
3
Vice Dean of Student’s Affair, Professor of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
AUTHOR
Mahmoud
Attia
4
Assistant Professor of Oral Pathology, Department of Oral Pathology, Faculty of Dental Medicine, Al-Azhar University, Assiut Branch, Egypt.
AUTHOR
Hend
Abdel-Hamid
5
Lecturer of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
AUTHOR
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ORIGINAL_ARTICLE
QUANTITATIVE ASSESSMENT OF TUMOR ASSOCIATED TISSUE EOSINOPHILIA IN ORAL SQUAMOUS CELL CARCINOMA (CLINICOPATHOLOGICAL STUDY).
ABSTRACT INTRODUCTION: Oral Squamous cell carcinoma (OSCC) is the 11th most common cancer worldwide. Tumor stroma consists of various inflammatory cells resulting from the host-response to tumor cell. Increased tissue eosinophil levels have been reported in various malignancies including OSCC. Tissue eosinophilia is a regular finding in allergic and parasitic disorders, but their role still needs to be evaluated in OSCCs. Specific stains as Congo red is a useful diagnostic means for detecting eosinophils owing to their distinctive quality to combine with eosinophils. OBJECTIVES: was to evaluate and compare eosinophilic infiltration in both metastatic and non-metastatic oral squamous cell carcinoma using Congo red stain and their correlation to the tumor grade. MATERIAL AND METHODS: Fifty histopathologically proven OSCC were included in this study and were allocated into 2 groups where the first group included 25 cases of metastatic OSCC and the remaining 25 cases are non-metastatic OSCC. Congo red was utilized as a distinct stain for eosinophils. Each specimen slide was inspected under high power in 10 successive microscopic fields to count eosinophils. RESULTS: the eosinophilic count was found to be higher in non-metastatic tumors when compared to metastatic tumors. CONCLUSION: eosinophilic count is a strong indicator of the stage of the tumor and its differentiation. KEY WORDS: Carcinoma, Congo Red, Eosinophils, Eosinophilia, Mouth Neoplasms, Squamous Cell.
https://adjalexu.journals.ekb.eg/article_127951_c75debccdd5e85aa46974350ed7d50ed.pdf
2021-04-01
72
77
10.21608/adjalexu.2020.21700.1034
carcinoma
Congo red
Eosinophils
Mouth Neoplasms
Squamous Cell
Mohamed
Deban
mohameddeban@gmail.com
1
Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
LEAD_AUTHOR
Fatma
El Didi
fatma.eldidi@alexu.edu.eg
2
Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
AUTHOR
Omneya
Ramadan
omneya2y@gmail.com
3
Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
AUTHOR
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