EVALUATION OF THE EFFECT OF STRONTIUM CITRATE ON BONE CONSOLIDATION DURING MANDIBULAR DISTRACTION OSTEOGENESIS IN RABBITS (EXPERIMENTAL STUDY)

Document Type : Original Article

Authors

1 Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

2 Professor of Oral and Maxillofacial Surgery, Alexandria University, Alexandria, Egypt.

3 Lecturer of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

4 Lecturer of Oral biology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Abstract

Introduction: Distraction osteogenesis is defined as an operation that can lengthen bone gradually. Many complications may occur during this time, including refractures, local infections and loosening of the distractor device or pin. The most important disadvantage applies to the extended period of consolidation stage. Several methods have been tested for their ability to enhance new bone development, including the use of different adjuvant therapies, in order to minimize the time needed to complete the MDO phases Strontium is a medication used for treatment of osteoporosis. It's been shown that bone formation is promoted while bone resorption is reduced and in osteoporotic patients.
Aim of this study: This study aimed to determine whether strontium citrate can be used in a rabbit model to enhance bone healing during MDO.
Materials and Methods: Fourteen rabbits weighing 3.0-3.5kg were divided into 2 groups: group I; (control group), group II; (received strontium citrate). Surgical procedures to place the distractor system were performed in both groups. After 5 days of latency period, the distractor was activated. After 4 weeks all rabbits were euthanized and the distracted mandibles were surgically removed and prepared for light microscopic examination and histomorphometry.
Results: Comparing to the control group, histological results revealed thicker bone trabeculae in the study group with narrower bone marrow. The histomorphometric analysis also showed significantly higher percentage of new bone per field in the study group.
Conclusions: Strontium citrate supplementation could enhance bone consolidation during distraction osteogenesis.

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Alexandria Dental Journal
Volume 46, Issue 3
A (Oral and maxillofacial surgery, oral medicine, periodontology, oral radiology, oral pathology, oral biology)
December 2021
Pages 59-64

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