EVALUATION OF ANTERIOR MAXILLARY HORIZONTAL RIDGE AUGMENTATION WITH SIMULTANOUS IMPLANT PLACEMENT USING CERABONE® VERSUS CERABONE® COMBINED WITH PLATELET RICH PLASMA (RANDOMIZED CLINICAL TRIAL)

Document Type : Original Article

Authors

1 BDS,2008, Faculty of Dentistry, Alexandria University, Egypt.

2 Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.

3 Lecturer of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Alexandria University, Egypt.

Abstract

Introduction: Rehabilitation of the anterior maxilla using dental implants is frequently problematic because of the deficiency of alveolar ridge width. Under certain conditions ridge augmentation with simultaneous implant placement is recommended.
Objectives:To evaluate horizontal augmentation of narrow anterior maxillary alveolar ridge with simultaneous implant placement using Cerabone® with and without platelet rich plasma (PRP).
Materials and Methods:In this study, 14 implants were placed in patients with insufficient alveolar ridge width in the maxillary lateral incisor region. Patients were divided into two groups; In Group “1” Cerabone® only was used as an augmentation material while in Group “2” a mixture of Cerabone® and PRP was used. A collagen membrane was used to cover the grafting material. Postoperative pain was assessed using visual analogue scale. Healing and postoperative edema were evaluated. Cone Beam Computed Tomography (CBCT) was obtained before surgery, immediately postoperatively and after 6 months so that the labial bone width and bone density were evaluated. Osstell was used to evaluate implant stability quotient (ISQ) during surgery and after 6 months.
Results:All implants in both groups were successfully osseointegrated and functionally stable. No significant difference in postoperative pain, edema or wound healing was detected between the two groups. The mean percentage of change in ISQ was superior in Group “2” when compared to Group “1”, but statistically there was no significant difference (P=0.898). The labial bone width in Group “2” was significantly higher than that of Group “1” (P=0.002). The mean percentage of change in labial bone density was 57.95% in Group “1” and 112.52% in Group “2” (P=0.848).
Conclusion:Cerabone® can be used effectively for guided bone regeneration around dental implant in narrow maxillary anterior alveolar ridges. Moreover, the addition of PRP has a positive effect on bone regeneration around implants.

Keywords

Main Subjects

References

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  22. Gopinath A, Ravikanth A, Kadiyala K, Thota K, Manne P, Babu M. Effect of platelet rich plasma on stability of dental implants: A prospective comparative clinical study. J NTR Univ Health Sci. 2017;6:107.
  23.  Thor A, Wannfors K, Sennerby L, Rasmusson L. Reconstruction of the Severely Resorbed Maxilla with Autogenous Bone, Platelet-Rich Plasma, and Implants: 1 -Year Results of a Controlled Prospective 5-Year Study. Clin Implant Dent Relat Res. 2005;7:209-220.
  24. Marukawa E, Oshina H, Iino G, Morita K, Omura K. Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft. J Craniomaxillofac Surg. 2011;39:278-83.
  25.  Eskan M, Greenwell H, Hill M, Morton D, Vidal R, Shumway B, et al. Platelet-Rich Plasma–Assisted Guided Bone Regeneration for Ridge Augmentation: A Randomized, Controlled Clinical Trial. J Periodontol. 2014;85:661-8.
  26. Deshpande R, Yadav A, Borle R, Kala A, Jajoo S, Thakkar D. Comparative efficacy of autologous alveolar bone grafting with autologous platelet-rich plasma and without platelet-rich plasma in cleft alveolus patients. J Cleft Lip Palate Craniofac Anomal. 2017;4:22.
  27. Sakio R, Sakamoto Y, Ogata H, Sakamoto T, Ishii T, Kishi K. Effect of Platelet-Rich Plasma on Bone Grafting of Alveolar Clefts. J Craniofac Surg. 2017;28:486-8.
  28. Lee S, Gantes B, Riggs M, Crigger M. Bone density assessments of dental implant sites: 3. Bone quality evaluation during osteotomy and implant placement. Int J Oral Maxillofac Implants. 2007;22:208-12.
  29.  Armstrong R. Acceptability of Cone Beam CT vs. Multi-Detector CT for 3D Anatomic Model Construction. J Oral Maxillofac Surg. 2006;64:37.
  30. Dong X, Petrongolo M, Niu T, Zhu L. Low-Dose and Scatter-Free Cone-Beam CT Imaging Using a Stationary Beam Blocker in a Single Scan: Phantom Studies. Comput Math Methods Med. 2013;2013:1-8.
  31. ArRejaie A, Al-Harbi F, Alagl A, Hassan K. Platelet-Rich Plasma Gel Combined with Bovine-Derived Xenograft for the Treatment of Dehiscence Around Immediately Placed Conventionally Loaded Dental Implants in Humans: Cone Beam Computed Tomography and Three-Dimensional Image Evaluation. Int J Oral Maxillofac Implants. 2016; 431-438.
  32. Kaushick B, Padmalatha O, Jayakumar N, Varghese S. Treatment of human periodontal infrabony defects with hydroxyapatite+ β tricalcium phosphate bone graft alone and in combination with platelet rich plasma: A randomized clinical trial. Indian J Dent Res. 2011;22:505.
  33. Khairy N, Shendy E, Askar N, El-Rouby D. Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial). Int J Oral Maxillofac Surg. 2013;42:249-55.
  34. Gupta C, Mehrotra D, Mohammad S, Khanna V, Kumar Singh G, Singh G et al. Alveolar bone graft with Platelet Rich Plasma in cleft alveolus. J Oral Biol Craniofac Res. 2013;3:3-8.
  35. Roffi A, Filardo G, Kon E, Marcacci M. Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review. BMC Musculoskelet Disord. 2013;14:330.

1.     Cole BJ, Seroyer ST, Filardo G, Bajaj S, Fortier LA. Platelet-rich plasma: where are we now and where are we going? Sports Health. 2010;2:203-10.

2.     Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638–646.

3.     Christensen D, Karoussis I, Joss A, Hammerle C, Lang N. Simultaneous or staged installation with guided bone augmentation of transmucosal titanium implants. A 3-year prospective cohort study. Clin Oral Implants Res. 2003;14:680-686.

4.     Fairbairn P, Leventis M. Protocol for Bone Augmentation with Simultaneous Early Implant Placement: A Retrospective Multicenter Clinical Study. Int J Dent 2015;2015:1-8.

5.     Lee J, Park H, Kim J, Choi Y, Kim Y, Huh J et al. A 5-year retrospective clinical study of the Dentium implants. J Adv Prosthodont. 2011;3:229.

6.     Caiazzo A, Brugnami F, Mehra P. Can placement of an immediate bone level tapered implant and subperiosteal xenograft help maintain bone architecture in esthetic areas?. J Oral Biol Craniofac Res. 2019;9:186-189.

7.     Forna D, Forna N, Earar K, Popescu E. Postoperative clinical evolution of edentulous patients treated by guided bone regeneration using xenograft bone substitute and collagen membrane. Mater Plast. 2017;54:312-315.

8.     Fukaya M, Ito A. A New Economic Method for Preparing Platelet-rich Plasma. Plast Reconstr Surg Glob Open. 2014;2:e162.

9.     Cieślik-Bielecka A, Pierchała M, Królikowska A, Reichert P. Effect of L-PRP treatment on wound healing after surgical skin incision in an experimental animal model. Connect Tissue Res. 2018;59:550-60.

10.Esposito M, Grusovin M, Maghaireh H, Worthington H. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database Syst Rev. 2013;28:CD003878

11.Lachmann S, Jäger B, Axmann D, Gomez-Roman G, Groten M, Weber H. Resonance frequency analysis and damping capacity assessment. Clin Oral Implants Res. 2006;17:75-79.

12.Zix J, Hug S, Kessler-Liechti G, Mericske-Stern R. Measurement of dental implant stability by resonance frequency analysis and damping capacity assessment: comparison of both techniques in a clinical trial. Int J Oral Maxillofac Implants. 2008;23:525-530.

13.Monov G, Fuerst G, Tepper G, Watzak G, Zechner W, Watzek G. The effect of platelet-rich plasma upon implant stability measured by resonance frequency analysis in the lower anterior mandibles. Clin Oral Implants Res. 2005;16:461-5.

14.Ergun G, Egilmez F, Cekic-Nagas I, Karaca İ, Bozkaya S. Effect of Platelet-Rich Plasma on the Outcome of Early Loaded Dental Implants: A 3-Year Follow-up Study. Oral Implantol. 2013;39:256-263.

15.Gopinath A, Ravikanth A, Kadiyala K, Thota K, Manne P, Babu M. Effect of platelet rich plasma on stability of dental implants: A prospective comparative clinical study. J NTR Univ Health Sci. 2017;6:107.

16.Thor A, Wannfors K, Sennerby L, Rasmusson L. Reconstruction of the Severely Resorbed Maxilla with Autogenous Bone, Platelet-Rich Plasma, and Implants: 1 -Year Results of a Controlled Prospective 5-Year Study. Clin Implant Dent Relat Res. 2005;7:209-220.

17.Marukawa E, Oshina H, Iino G, Morita K, Omura K. Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft. J Craniomaxillofac Surg. 2011;39:278-83.

18.Eskan M, Greenwell H, Hill M, Morton D, Vidal R, Shumway B, et al. Platelet-Rich Plasma–Assisted Guided Bone Regeneration for Ridge Augmentation: A Randomized, Controlled Clinical Trial. J Periodontol. 2014;85:661-8.

19.  Deshpande R, Yadav A, Borle R, Kala A, Jajoo S, Thakkar D. Comparative efficacy of autologous alveolar bone grafting with autologous platelet-rich plasma and without platelet-rich plasma in cleft alveolus patients. J Cleft Lip Palate Craniofac Anomal. 2017;4:22.

20.Sakio R, Sakamoto Y, Ogata H, Sakamoto T, Ishii T, Kishi K. Effect of Platelet-Rich Plasma on Bone Grafting of Alveolar Clefts. J Craniofac Surg. 2017;28:486-8.

21.Lee S, Gantes B, Riggs M, Crigger M. Bone density assessments of dental implant sites: 3. Bone quality evaluation during osteotomy and implant placement. Int J Oral Maxillofac Implants. 2007;22:208-12.

22.Armstrong R. Acceptability of Cone Beam CT vs. Multi-Detector CT for 3D Anatomic Model Construction. J Oral Maxillofac Surg. 2006;64:37.

23.Dong X, Petrongolo M, Niu T, Zhu L. Low-Dose and Scatter-Free Cone-Beam CT Imaging Using a Stationary Beam Blocker in a Single Scan: Phantom Studies. Comput Math Methods Med. 2013;2013:1-8.

24.  ArRejaie A, Al-Harbi F, Alagl A, Hassan K. Platelet-Rich Plasma Gel Combined with Bovine-Derived Xenograft for the Treatment of Dehiscence Around Immediately Placed Conventionally Loaded Dental Implants in Humans: Cone Beam Computed Tomography and Three-Dimensional Image Evaluation. Int J Oral Maxillofac Implants. 2016; 431-438.

25.Kaushick B, Padmalatha O, Jayakumar N, Varghese S. Treatment of human periodontal infrabony defects with hydroxyapatite+ β tricalcium phosphate bone graft alone and in combination with platelet rich plasma: A randomized clinical trial. Indian J Dent Res. 2011;22:505.

26.Khairy N, Shendy E, Askar N, El-Rouby D. Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial). Int J Oral Maxillofac Surg. 2013;42:249-55.

27.Gupta C, Mehrotra D, Mohammad S, Khanna V, Kumar Singh G, Singh G et al. Alveolar bone graft with Platelet Rich Plasma in cleft alveolus. J Oral Biol Craniofac Res. 2013;3:3-8.

28.Roffi A, Filardo G, Kon E, Marcacci M. Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review. BMC Musculoskelet Disord. 2013;14:330.

 

Alexandria Dental Journal
Volume 46, Issue 2
A (Oral and maxillofacial surgery, oral medicine, periodontology, oral radiology, oral pathology, oral biology)
August 2021
Pages 1-7

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