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abu ayana, M., Ali, H., Kawana, K., Fahmy, R., Hamza, S. (2022). ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS. Alexandria Dental Journal, 47(1), 75-81. doi: 10.21608/adjalexu.2021.71539.1183
mariam abdel aziz abu ayana; Hanaa mohamed Ali; Khadiga yossef Kawana; Rania abdelaziz Fahmy; Sara Ashraf Hamza. "ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS". Alexandria Dental Journal, 47, 1, 2022, 75-81. doi: 10.21608/adjalexu.2021.71539.1183
abu ayana, M., Ali, H., Kawana, K., Fahmy, R., Hamza, S. (2022). 'ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS', Alexandria Dental Journal, 47(1), pp. 75-81. doi: 10.21608/adjalexu.2021.71539.1183
abu ayana, M., Ali, H., Kawana, K., Fahmy, R., Hamza, S. ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS. Alexandria Dental Journal, 2022; 47(1): 75-81. doi: 10.21608/adjalexu.2021.71539.1183

ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS

Article 12, Volume 47, Issue 1, April 2022, Page 75-81  XML PDF (644.99 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2021.71539.1183
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Authors
mariam abdel aziz abu ayana email 1; Hanaa mohamed Ali2; Khadiga yossef Kawana2; Rania abdelaziz Fahmyorcid 3; Sara Ashraf Hamza4
1Oral biology department faculty of dentistry alexandria university
2Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt
3Assistant Professor, Oral Medicine and Periodontology, Faculty of Dentistry, Alexandria University, Alexandria City, Egypt
4lecturer of oral biology ,faculty of dentistry, Alexandria university, Alexandria, Egypt
Abstract
Background: Nowadays, the application of nanotechnology is recommended for potential treatments in dentistry. Curcumin nanoparticles (CURN) have been found to possess potential antioxidant and anti-inflammatory activities that can treat periodontitis which is considered as an inflammatory disorder that can spread down the gingiva causing alveolar bone destruction.
Objectives: To evaluate the biological effect of CURN on alveolar bone structure in rats with ligature induced periodontitis.
Materials and Methods: Thirty-five healthy adult male albino rats were divided into 3 groups: Group A (control group), Group B (periodontitis group) and Group C (curcumin nanoparticles treated group). A silk ligature was used to induce periodontitis in group B and C. After two weeks, the ligature was removed. CURN was then administrated orally to rats of group C (15 mg/kg/day). The animals were euthanized by the end of the experimental periods, after 2 and 4 weeks from removal of ligature. Right side mandibles were dissected out and prepared for scanning electron microscope (SEM) and energy dispersive x-ray microanalysis (EDX).
Results: Scanning electron microscopic results revealed restoration of the alveolar bone level around mandibular first molar with decrease in the porosity in the surface of the alveolar bone in group C treated with CURN rather than in periodontitis group B. These results were confirmed by EDX which showed more calcium and less phosphorous percentage in group C than in group B.
Conclusions: Curcumin nanoparticles have a positive biological effect on alveolar bone structure in rats with ligature induced periodontitis.
Key words: Curcumin nanoparticles, anti-inflammatory, periodontitis
Keywords
Curcumin nanoparticles; anti-inflammatory; periodontitis
Main Subjects
Oral biology
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