HISTOLOGICAL EVALUATION OF ANGELICA SINENSIS IN MANAGEMENT OF CLASS II FURCATION DEFECT (AN EXPERIMENTAL STUDY)

Document Type : Original Article

Authors

1 periodontology, faculty of dentistry, Alexandria university , Egypt

2 Professor, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University

3 Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology Department , Faculty of dentistry , Alexandria university

4 Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt

Abstract

Introduction: proper management of furcation involvements has always been a demanding issue in periodontal therapy. Herbal medicine is nowadays proposed to provide novel alternative approaches for restoring defective bone. A Chinese herb known as Angelica sinensis (As) has various pharmacological effects as it promotes proliferation and differentiation of osteoblasts
Objectives: The aim of this study was to evaluate the effectiveness of Angelica sinensis in conjunction with β-tricalcium phosphate in the management of class II furcation defects in dogs
Materials and Methods: This randomized study was carried on 6 clinically healthy mongrel dogs. 24 grade II critical-sized furcation defects were surgically created in the mandibular third and fourth premolars. 12 defects were filled with Beta-tricalcium phosphate (β-TCP) bone graft only (control group). While in the other 12 defects β-TCP was mixed with Angelica sinensis powder (experimental group). The defects were covered by collagen membrane, The dogs were sacrificed at 4 and 8 weeks postoperative.
Results: The histological analysis has revealed better regenerative features regarding alveolar bone, periodontal ligament and cementum in the experimental groups when compared to control groups.
Conclusions: Angelica sinensis herb could enhance the periodontal regenerative potential of β-TCP bone graft.

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Alexandria Dental Journal
Volume 48, Issue 3
A (Oral and maxillofacial surgery, oral medicine, periodontology, oral radiology, oral pathology, oral biology)
December 2023
Pages 62-69

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