Ayad, E., Abou Khadr, M., Ayad, M., El-Kimary, G. (2024). ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]. Alexandria Dental Journal, 49(3), 7-13. doi: 10.21608/adjalexu.2023.201324.1360
Emad Said Ayad; Maha Abd El Aziz Abou Khadr; Mona Wagdy Ayad; Gillan Ibrahim El-Kimary. "ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]". Alexandria Dental Journal, 49, 3, 2024, 7-13. doi: 10.21608/adjalexu.2023.201324.1360
Ayad, E., Abou Khadr, M., Ayad, M., El-Kimary, G. (2024). 'ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]', Alexandria Dental Journal, 49(3), pp. 7-13. doi: 10.21608/adjalexu.2023.201324.1360
Ayad, E., Abou Khadr, M., Ayad, M., El-Kimary, G. ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]. Alexandria Dental Journal, 2024; 49(3): 7-13. doi: 10.21608/adjalexu.2023.201324.1360
ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]
1Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria ,Egypt
2Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
3Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
4Lecturer of periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University
Abstract
Background: Clinical parameters are used to diagnose periodontal disease. However, new technical advances in diagnostics for assessing periodontal status are utilizing objective biomarkers. Recently, a number of biomarkers have been identified to predict periodontitis status. Endocan is a novel pro-inflammatory biomarker that is thought to give an insight on periodontal disease status. Objective: Evaluation of Endocan level in gingival crevicular fluid (GCF) of stage 1 and 2 periodontitis patients with or without type 2 diabetes mellitus. Materials and Methods: 42 patients with stage 1 and 2 periodontitis were divided into two groups: 23 patients with controlled type 2 diabetes mellitus (CT2DM-P) and 19 systemically healthy periodontitis patients (H-P). Endocan level in GCF, periodontal parameters, and Hemoglobin A1c (HbA1c) value were measured. Biochemical analysis of Endocan level was performed by enzyme-linked immunosorbent assay (ELISA). Results: GCF Endocan level was significantly higher in the CT2DM-P group than in the H-P group. Mean pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing percentage (BOP%) were higher in the CT2DM-P group. Endocan was positively correlated to CAL, BOP%, and HbA1c in both groups, with Endocan and BOP% having a moderate correlation in the CT2DM-P group and Endocan and HbA1c having a strong correlation in the H-P group. Conclusion: Endocan levels, PPD, CAL, and BOP% in CT2DM-P group were higher than H-P group. Positive correlations between BOP%, Glycated hemoglobin and Endocan were also observed.
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