elsayes, S., EL-Attar, M., elhadary, A., aboulela, A., Hassan, I. (2025). THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL). Alexandria Dental Journal, 50(1), 163-167. doi: 10.21608/adjalexu.2024.258482.1458
salma abdelaziz elsayes; Mohamed Sherine EL-Attar; Amany ahmed elhadary; aliaa gamaleldin aboulela; Ingy Hassan. "THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL)". Alexandria Dental Journal, 50, 1, 2025, 163-167. doi: 10.21608/adjalexu.2024.258482.1458
elsayes, S., EL-Attar, M., elhadary, A., aboulela, A., Hassan, I. (2025). 'THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL)', Alexandria Dental Journal, 50(1), pp. 163-167. doi: 10.21608/adjalexu.2024.258482.1458
elsayes, S., EL-Attar, M., elhadary, A., aboulela, A., Hassan, I. THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL). Alexandria Dental Journal, 2025; 50(1): 163-167. doi: 10.21608/adjalexu.2024.258482.1458
THE PREVENTIVE EFFECT OF PROBIOTICS CONCERNING NEW DENTURE WEARERS IN ORAL CANDIDIASIS (CLINICAL TRIAL)
2Prosthodontics Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
3Faculty of Oral and Dental Medicine, Future University, Cairo, Egypt.
4Microbiology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
5prosthodontics department faculty of dentistry Alexandria, Egypt
Abstract
Introduction: The most common therapeutic strategy for oral candidiasis is using antifungal agents, Unfortunately, the prolonged administration of antifungals has many adverse effects. There is an increasing demand for a potent antifungal agent against oral candidiasis (OC) with the least adverse effect and low recurrence rate. Objectives: To evaluate the preventive effect of a daily dose of commercial probiotics on the oral Candida spp. colonization in new denture wearers during probiotics administration and 4 weeks after the end of probiotics intake. Material and Methods: The current clinical trial included 48 new complete denture wearers with detectable levels of Candida but without clinical symptoms. Participants in the probiotics group received a daily dose of probiotics lozenges for eight weeks versus the placebo tablets taken by the participants in the placebo group. Microbiological mouth-rinse samples determined the Candida count at different time intervals: baseline, two weeks after denture delivery, after 4 and 8 weeks of intervention, and four weeks post-intervention follow-up. Results: Probiotics significantly reduced Candida count compared to placebo in the fourth week and subsequent follow-up periods. In the eighth week, they had the highest decrease (p < 0.0001). Conclusion: Probiotic lozenges were highly effective against fungal infections in new denture wearers, with short-term preventive effects even after intervention cessation.
View on SCiNiTO
Top