EVALUATION OF THE EFFECT OF CHOLECALCIFEROL AND CALCIUM ON A DELAYED DENTAL IMPLANT ON POST-MENOPAUSAL FEMALES

Document Type : Original Article

Authors

1 - Bachelor of Dentistry, BDS, Faculty of Dentistry, 6October University, Cairo, Egypt.

2 - Professor of Oral and Maxillofacial Surgery, BDS, MSc, PhD, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

3 - Lecturer of Oral and Maxillofacial Surgery, BDS, MSc, PhD, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Abstract

INTRODUCTION: The replacement of the natural teeth has been the aim of mankind since ancient time. That’s why we use dental implant and its osseointegration should be enhanced. By using Cholecalciferol and Calcium on postmenopausal females. OBJECTIVES: The aim of the study was to evaluate the effect of combination of cholecalciferol and calcium on delayed dental implants healing for postmenopausal females. MATERIALS AND METHODS: A clinical and radiographical study was carried out on 14 postmenopausal female patients with age range from 40 to 60 years having missing maxillary anterior teeth. All the patients received the same implant system. The study group only received cholecalciferol and calcium for 8 months and the control group didn’t receive thing. After placement all implants were evaluated clinically after 4 and 8 months (modified gingival index, papillary bleeding index, and degree of mobility) and radiographically after 4 and 8 months to evaluate marginal bone loss. RESULTS The study group showed an increase in bone density. Group I(study): was better with a mean of (120.8±39.53) pixel while Group II(control): showed a mean of (90.84±41.6) pixel the difference of the bone density between the two groups was statistically significant (p=0.008). CONCLUSIONS: The implant placement in postmenopausal female patients may be successful. Cholecalciferol and calcium has systemic effects on accelerating bone formation around titanium implants

Keywords

References

1. lsaksson S. Evaluation of three bone grafting techniques for severely resorbed maxilla in conjunction with immediate endosseous implants. Int J Oral Maxillofac Implants. 1994;9:679-88.
2. Covani U, Bortolaia C, Barone A, Sbordone L. Buccolingual crestal bone changes after immediate and delayed placement. J Periodontol. 2004;75:1605-12.
3. Ogismo M, Tabata T, Lee RR, Borgese D. Delay method of implantation enhances implant-bone binding: A comparison with the conventional method. Int J Oral Maxillofac Implants. 1995;10:415–20.
4. Marco F, Milena F, Gianluca G, Vittoria O. Periimplant osteogenesis in health and osteoporosis. Micron. 2005;36:630-44.
5. Linder L, Obrant K, Boivin G. Osseointegration of metallic implants. II. Transmission electron microscopy in the rabbit. ActaOrthop Scand. 1989;60:135-9.
6. Soballe K. Hydroxyapatite ceramic coating for bone implant fixation. Mechanical and histological studies in dogs. ActaOrthopScand Suppl. 1993;255:1-58. 7. Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM. The biology of bone grafting. J Am AcadOrthop Surg. 2005;13:77-86.
8. Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma. 1989;3:192-5.
9. Eberhardt C, Habermann B, Müller S, Schwarz M, Bauss F, Kurth AH. The bisphosphonate ibandronate accelerates osseointegration of hydroxyapatite-coated cementless implants in an animal model. J Orthop Sci. 2007;12:61-6.
10. Başarir K, Erdemli B, Can A, Erdemli E, Zeyrek T. Osseointegration in arthroplasty: can simvastatin promote bone response to implants? IntOrthop. 2009;33:855-9.
11. Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, et al. A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res. 2006;21:836-44.
12. Schedlich LJ, Muthukaruppan A, O'Han MK, Baxter RC. Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts. MolEndocrinol. 2007;21:2378-90.
13. Shiraishi A, Higashi S, Ohkawa H, Kubodera N, Hirasawa T, Ezawa I, et al. The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis. Calcif Tissue Int. 1999;65:311-6.
14. Sairanen S, Kärkkäinen M, Tähtelä R, Laitinen K, Mäkelä P, Lamberg-Allardt C, et al. Bone mass and markers of bone and calcium metabolism in postmenopausal women treated with 1,25-dihydroxyvitamin D (calcitriol) for four years. Calcif Tissue Int. 2000;67:122-7.
15. Macdonald HM, Wood AD, Aucott LS, Black AJ, Fraser WD, Mavroeidi A, et al. Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1 year doubleblind RCT in postmenopausal women. J Bone Miner Res. 2013;28:2202-13.
16. Pasqualini D, Cocero N, Castella A, Mela L. Primary and secondary closure of the surgical wound removal of the impacted mandibular 3rd molar: a comparative study. Int J MaxillofacSurg 2005;34:52-7.
17. Mckinney R, Koth D, Steflik D. Clinical standards for dental implant. In: Clark JW (ed). Clinical dentistry. Harperstwon: Harper and Row, 1998;1-11.
18. Muhlemann HR. Physiology and chemical mediators of gingival health. J Prev Dent 1977; 4:6-20.
19. Beer A, Gahleitner A, Holm A, Tschabitscher M, HomolkaP.Corelation of insertion torques with bone mineral density from dental quantitative CT in the mandible.Clin Oral Implants Res 2003; 14:616-20.
20. Bornstein MM, Cionca N, Mombelli A. Systemic conditions and treatments as risks for implant therapy. Int J Oral Maxillofac Implants 2009; 24: 12-27.
21. Leonhardt A, Dahlen G, Renvert S. Five- year clinical, microbiological and radiological outcome following treatment of peri- implantitis in man. J Periodontol 2003; 74: 1415-22.
22. Elsubeihi E, Zarb G. Implant Prosthodontics in Medically Challenged Patients. J Can Dent Assoc.2002; 68(2): 103-8.
23. Al-Sabbagh M, Bhavsar I. Key local and surgical factors related to implant failure. Dent Clin North Am 2015; 59: 1- 23.
24.Becker W, Becker B. Guided tissue regeneration for implants placed into extraction socket and for implant dehiscence: Surgical techniques and case reports. Int J PeriodontRestor Dent. 1990;10:376-91.
25.Elsubeihi E, Zarb G. Implant Prosthodontics in Medically Challenged Patients. J Can Dent Assoc. 2002;68:103-8.
26.Mori H, Manabe M, Kurachi Y, Nagume M. Osseointegration of dental implants in rabbits with low mineral density. J Oral Maxillofac Surg. 1997;55:351-61.
27.Brånemark PI. Osseointegration and its experimental studies. J Prosthet Dent. 1983;50:399-410.
28.Ciancio S, Lauciello F, Shibly O, Vitello M, Mather M. The effect of an antiseptic mouthrinse on implant maintenance: plaque and peri implant gingival tissues. J Periodontol. 1995;66(11):962-5.
29.Beilker T, Flemmig F. Implant in the medically compermised patients. Crit Rev Oral Biol Med. 2003;14:305-16.
30.Dao T, Anderson J, Zarb G. Is osteoporosis a risk factor for osseointegration of dental implants? Int J Oral Maxillofac Implants. 1993;8:137-44.
31.Porter J, Von Fraunhofer J. Success or failure of dental implants? A literature review with treatment considerations. General Dent. 2005;53:423-32.
32.Loe H, Silness J. The Gingival Index, the Plaque Index and the Retention Index system. J Periodontol. 1967;38:610.
33.Joly J, de Lima A, Da Silva R. Clinical and radiographic evaluation of soft and hard tissue changes around implants; A pilot study. J Periodontol. 2003;74:1097-103.
34.Shimpuku H, Nosaka Y, Kawamura T, Tachi Y, Shinohara M, Ohura K. Genetic polymorphism of interleukin-1 gene and early marginal bone loss around endosseous dental implants. Clin Oral Implants Res. 2003;14:423-9.
35.Yunus B. Assessment of the increased calcification of the jaw bone with CT-Scan after dental implantplacement. Imaging Sci Dent 2011; 41: 59-62
36.Zhou XQ, Hu J, Du ZJ, Yang JH, Liu M, Li XM. Oestrogen replacement therapy promotes bone healing around dental implants in osteoporotic rats. Int J Oral Maxillofac Surg. 2004;33:279–285.
37.Fulker K.Update on bone density measurement. Rheum Dis Clin North Am. 2001;27:81-99.

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