EFFICACY OF QUERCETIN ON ALVEOLAR BONE STRUCTURE OF RATS WITH INDUCED DIABETES

Abu Ayana, Mariam A.; Elmasry, Nawal A.; Shehata, Fathy I.; Khalil, Nesma M.

doi:10.21608/adjalexu.2017.57917

EFFICACY OF QUERCETIN ON ALVEOLAR BONE STRUCTURE OF RATS WITH INDUCED DIABETES

Document Type : Original Article

Authors

¹ Demonstrator of oral biology, Faculty of dentistry, Alexandria University

² Professor of oral biology, Faculty of Dentistry, Alexandria University.

³ Lecturer of oral biology, Faculty of Dentistry, Alexandria University.

10.21608/adjalexu.2017.57917

Abstract

INTRODUCTION: Diabetic osteopenia is the sixth classic complication of Diabetes mellitus. High glucose level is capable of triggering increased oxidative stress which induce osteoblast apoptosis. Quercetin, a powerful natural antioxidant, can protect many organs against oxidative damage, including bone. OBJECTIVES: The present study is designed to investigate the effect of quercetin administration on the alveolar bone in rats with induced diabetes. MATERIALS AND METHODS: Twenty-four adult male rats were divided into three equal groups (8 rats each) as follows: Group I: Control group, Group II: diabetic group (with no treatment), Group III: quercetin treated group (induction of diabetes with oral administration of quercetin dose 100mg/ kg/ day for 12 weeks). Diabetes was induced in group II and group III by a single intraperitoneal injection of Streptozotocin (STZ). After 12 weeks all rats were sacrificed and the mandibles were dissected out and prepared for histological analysis using scanning electron microscope (SEM), and energy dispersive x-ray microanalysis (EDX). RESULTS: In diabetic group, there was significant increase in blood sugar level. Bone surface revealed irregular surface with multiple resorptive pits. Moreover, there was significant decrease in calcium level and increase in phosphorous level while in quercetin group. Both blood sugar level and alveolar bone surface relatively returned back to normal. Also there was slight decrease in calcium and increase in phosphorous in comparison to control group. CONCLUSIONS: Quercetin exerts protective effects on STZ-induced oxidative stress in diabetic rats restoring the architecture of bone.

Keywords

Main Subjects

Oral biology

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