EVALUATION OF LOCAL ADMINISTRATION OF SIMVASTATIN ON HEIGHT AND WIDTH OF THE HEALING EXTRACTION SOCKET IN RAT MANDIBLE

Sherif, Youmna M.; El Masry, Nawal; Karam, Sahar S.; Nasra, Maha A.

doi:10.21608/adjalexu.2016.58040

EVALUATION OF LOCAL ADMINISTRATION OF SIMVASTATIN ON HEIGHT AND WIDTH OF THE HEALING EXTRACTION SOCKET IN RAT MANDIBLE

Document Type : Original Article

Authors

¹ BDS, Faculty of Dentistry Alexandria University

² PhD, Professor of oral biology - Faculty of Dentistry - Alexandria University

³ PhD, Professor of oral biology - Faculty of Dentistry - Alexandria University.

⁴ PhD, Lecturer of Pharmaceutics-Faculty of Pharmacy-Alexandria University.

10.21608/adjalexu.2016.58040

Abstract

INTRODUCTION: studies concerning healing of extraction sockets revealed that sockets were filled with new bone by as much as two thirds in 40 days and completely filled with new bone in 10 weeks. There have been many studies demonstrating the bone-promoting effect of simvastatin local application in animal models. Simvastatin was shown to increase bone volume, bone formation rate, and bone compressive strength. The use of statins for bone regeneration is a promising and growing area of research. OBJECTIVES: The aim of this study was to compare between the amounts of resorption that occurs in the healing extraction socket left to heal spontaneously to the amount of resorption that occurs in the healing extraction socket filled with simvastatin gel. MATERIALS AND METHODS: Right and left first molars were extracted from 20 rats’ mandibles’. Right side extraction sockets (Experimental) were filled with 2.5% simvastatin gel, while the left side sockets (Controls) were allowed to heal spontaneously. The rats were humanely sacrificed at 1st,2nd,3rd and 4th week postoperatively, and the specimens’ height and width were measured using a bone caliper. RESULTS: The mid-buccal height as well as the buccolingual width of the alveolar bone on the simvastatin-treated side was relatively higher and thicker than the control side indicating that less resorption had occurred on that side. CONCLUSIONS: The present study provided evidence that a single topical application of 2.5% simvastatin gel improve the quality of the new bone of the healing extraction socket and decreases bone resorption.

Keywords

Main Subjects

Oral biology

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