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Emam, S., Issa, N., El-Attar, M. (2019). EVALUATION OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISM 1772C>T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION. Alexandria Dental Journal, 44(3), 50-55. doi: 10.21608/adjalexu.2019.63556
Samar M. Emam; Noha M. Issa; Mohamed S. El-Attar. "EVALUATION OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISM 1772C>T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION". Alexandria Dental Journal, 44, 3, 2019, 50-55. doi: 10.21608/adjalexu.2019.63556
Emam, S., Issa, N., El-Attar, M. (2019). 'EVALUATION OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISM 1772C>T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION', Alexandria Dental Journal, 44(3), pp. 50-55. doi: 10.21608/adjalexu.2019.63556
Emam, S., Issa, N., El-Attar, M. EVALUATION OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISM 1772C>T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION. Alexandria Dental Journal, 2019; 44(3): 50-55. doi: 10.21608/adjalexu.2019.63556

EVALUATION OF THE EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISM 1772C>T IN HIF-α GENE ON THE RESIDUAL RIDGE RESORPTION OF THE MANDIBLE IN THE EGYPTIAN POPULATION

Article 9, Volume 44, Issue 3, December 2019, Page 50-55  XML PDF (339.89 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2019.63556
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Authors
Samar M. Emam email 1; Noha M. Issa2; Mohamed S. El-Attar3
1Dentist at the Alexandria University Students’ clinic, Alexandria University, Alexandria, Egypt
2Lecturer of Human Genetics, Medical Research Institute, Alexandria University, Alexandria, Egypt
3Professor of Prosthodontics, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Abstract
INTRODUCTION: Atrophic residual ridges have always been an obstacle for a successful prosthodontics treatment. Residual ridge resorption (RRR) was attributed to a combination of anatomical, metabolic and mechanical determinants. Lately, the genetic factor was considered since single nucleotide polymorphisms (SNPs) in relevant genes have been present in patients having severe RRR. OBJECTIVES: The aim of the current study was to investigate for the first time the relation between SNP 1772C>T in Hypoxia Inducible Factor-1 alpha (HIF-1α) gene and the presence of severely resorbed edentulous mandibular ridges in a sample of the Egyptian population. MATERIALS AND METHODS: The study was conducted on 50 subjects divided into case and control groups according to the residual ridge height. Saliva was used as a convenient source of DNA in the dental clinic. PCR-Restriction Fragment Length Polymorphism was performed for genotyping. RESULTS: A statistically significant difference in the distribution of the TT genotype between both groups was present. There was also a difference in the distribution of the CC and CT genotypes but it wasn’t statistically significant. The T alleles were more abundant in the case group while the control group showed more frequency of the C allele with no statistical significance. CONCLUSIONS: This study concluded that the TT genotype of the 1772C>T polymorphism of HIF-1α gene is related to the presence of severely atrophied residual ridges. This SNP can be used as a marker to predict the future condition of the ridge using saliva samples. Further studies on larger scale are recommended.
Keywords
Edentulous mandible; Genetics; Hypoxia inducible factor-1 alpha (HIF1-α); Residual ridge resorption (RRR); Single nucleotide polymorphisms (SNPs)
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