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Mostafa, H., Shehata, F., Omar, S., Kawana, K. (2020). THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS. Alexandria Dental Journal, 45(1), 34-38. doi: 10.21608/adjalexu.2020.79929
Hossam M. Mostafa; Fathy I. Shehata; Samia O. Omar; Khadiga Y. Kawana. "THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS". Alexandria Dental Journal, 45, 1, 2020, 34-38. doi: 10.21608/adjalexu.2020.79929
Mostafa, H., Shehata, F., Omar, S., Kawana, K. (2020). 'THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS', Alexandria Dental Journal, 45(1), pp. 34-38. doi: 10.21608/adjalexu.2020.79929
Mostafa, H., Shehata, F., Omar, S., Kawana, K. THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS. Alexandria Dental Journal, 2020; 45(1): 34-38. doi: 10.21608/adjalexu.2020.79929

THE EFFECT OF AMOXICILLIN ON THE SECRETORY STAGE OF AMELOGENESIS IN RATS

Article 6, Volume 45, Issue 1, April 2020, Page 34-38  XML PDF (289.33 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2020.79929
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Authors
Hossam M. Mostafa email 1; Fathy I. Shehata2; Samia O. Omar2; Khadiga Y. Kawana2
1Master of science degree in Oral Biology 2015, Alexandria University
2Professor of Oral Biology, Faculty of Dentistry, Alexandria University.
Abstract
Introduction: Molar–incisor hypomineralization is a developmental enamel defect affecting first permanent molars and incisors. The intake of antibiotics during pregnancy and early childhood has been associated with molar incisor hypomineralization.
Objectives: Was to determine the effect of amoxicillin on the secretory a stage of amelogenesis histologically and histomorphometrically.
Materials and methods: Fourteen pregnant rats were randomly assigned to two groups that received physiological solution (control group), 250 mg/kg/day amoxicillin (study group). Directly after birth, fourteen pups representing each group received the same treatment with dose equivalent to their body weight then they were euthanized at day 7 birth. The ameloblasts of developing molars were examined histologically and histomorphometrically.
Results:In day 7 after birth, the ameloblasts in control group revealed normal features of amelogenesis while in study group, numerous vacuolar like structures were seen in between secretory ameloblasts.
Conclusions: Amoxicillin disrupts the normal structure of enamel and impairs the secretion of enamel matrix
Keywords
Ameloblast; amoxicillin; secretory; amelogenesis
Main Subjects
Oral biology
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