Abd EL Hafez, D., Ali, T., El Ashwah, A. (2021). EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY). Alexandria Dental Journal, 46(Issue 1), 6-14. doi: 10.21608/adjalexu.2021.144906
Dina M. Abd EL Hafez; Tarek M. Ali; Adham A. El Ashwah. "EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY)". Alexandria Dental Journal, 46, Issue 1, 2021, 6-14. doi: 10.21608/adjalexu.2021.144906
Abd EL Hafez, D., Ali, T., El Ashwah, A. (2021). 'EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY)', Alexandria Dental Journal, 46(Issue 1), pp. 6-14. doi: 10.21608/adjalexu.2021.144906
Abd EL Hafez, D., Ali, T., El Ashwah, A. EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY). Alexandria Dental Journal, 2021; 46(Issue 1): 6-14. doi: 10.21608/adjalexu.2021.144906
EVALUATION OF CHITOSAN/HYDROXYAPATITE SCAFFOLD ON THE HEALING OF OSSEOUS DEFECTS IN JAW BONES (CLINICAL STUDY)
1BDS, MS, Faculty of Dentistry, Alexandria University.
2Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University
3Assistant Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University.
Abstract
INTRODUCTION: The repair and replacement of injured or defective bone is a critical problem in orthopedic treatment. Bone defects in the maxillofacial region are considered a serious health problem. The correct restoration of architecture and function of tissues of this important anatomical region is mandatory. A variety of methods are employed for treating such defects, however, each of the strategies has its own drawbacks. Significant development has been achieved with combining bioceramics and biopolymers. Chitosan/ nano-Hydroxyapatite (CH/nHA) has recently emerged a new strategy for promoting bone regeneration and enhancement of bone healing and remodeling. This composite has increased cell adhesion, cell proliferation, mechanical strength, alkaline phosphatase activity, protein adsorption, type I collagen production as well as expression of other osteogenic differentiation markers. OBJECTIVES: The aim of the present study is to assess the effectiveness of using Chitosan/ nano-Hydroxyapatite composite on healing and regeneration of bony defects of the jaws radiograhicaly by the aid of Cone beam computed tomography. METHODOLOGY: This study was performed on 14 patients having bone defects in their maxilla or mandible due to cysts or tumors. Patients were divided into two groups; test group in which patients had removal of bone lesion leaving bone defects treated with Chitosan/nano-Hydroxyapatite, and control group in which bone defects were left to heal spontaneously. Bone defects were examined radiographically using Cone beam computed tomography. RESULTS: A significant increase in bone density in bone defects treated with Chitosan/nano-hydroxyapatite, as well as significant decrease in bone defect size.
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