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Alexandria Dental Journal
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Journal Archive
Volume Volume 50 (2025)
Issue Issue 1
A (Oral and maxillofacial surgery, oral medicine, periodontology, oral radiology, oral pathology, oral biology)
Issue Issue 1
B (Endodontics, Prosthodontics, Fixed prosthodontics, Conservative dentistry, Dental Biomaterials)
Issue Issue 1
C (Pediatric dentistry, Dental public health, Orthodontics)
Volume Volume 49 (2024)
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Volume Volume 47 (2022)
Volume Volume 46 (2021)
Volume Volume 45 (2020)
Volume Volume 44 (2019)
Volume Volume 43 (2018)
Volume Volume 42 (2017)
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Volume Volume 40 (2015)
Sakr, S., Abdelmajeed, S., El-Adway, M., Nagui, D. (2025). THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS. Alexandria Dental Journal, 50(1), 76-82. doi: 10.21608/adjalexu.2023.240759.1418
Sally Samir Sakr; Shadia Hussein Abdelmajeed; Mounir Mohmoud El-Adway; Dina A. Nagui. "THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS". Alexandria Dental Journal, 50, 1, 2025, 76-82. doi: 10.21608/adjalexu.2023.240759.1418
Sakr, S., Abdelmajeed, S., El-Adway, M., Nagui, D. (2025). 'THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS', Alexandria Dental Journal, 50(1), pp. 76-82. doi: 10.21608/adjalexu.2023.240759.1418
Sakr, S., Abdelmajeed, S., El-Adway, M., Nagui, D. THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS. Alexandria Dental Journal, 2025; 50(1): 76-82. doi: 10.21608/adjalexu.2023.240759.1418

THERAPEUTIC EFFECT OF FLAXSEEDS ON OSTEOPOROSIS IN ALVEOLAR BONE OF RATS

Article 11, Volume 50, Issue 1, April 2025, Page 76-82  XML PDF (530.17 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2023.240759.1418
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Authors
Sally Samir Sakr email 1; Shadia Hussein Abdelmajeed2; Mounir Mohmoud El-Adway3; Dina A. Nagui4
1Oral biology, faculty of dentistry, Alexandria university, Alexandria, Egypt.
2Professor of Oral Biology, Faculty of Dentistry, Alexandria University
3Animal Production Department, Faculty of Agriculture Alexandria University.
4Assistant Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University
Abstract
Background: Osteoporosis is a bone disorder, occurs due to disruption of bone remodeling. Primary osteoporosis is observed in post-menopausal women and aging population. Glucocorticoids are implicated as a main cause for secondary osteoporosis. Pharmacological treatments for osteoporosis cause adverse effects thus using natural herbs is preferable. Flaxseeds may has a key role in enhancing bone mass.
Objectives: To assess the therapeutic efficacy of flaxseeds against glucocorticoids induced osteoporosis in alveolar bone of rats.
Materials and Methods: A total of 45 adult albino female rats were divided into three equal groups, Control group I, Glucocorticoid group II and Flaxseed treated group III. All rats will be fed on basal diet (BD). Rats in group II and III received Methylprednisolone 5 mg/kg 5 days per week by subcutaneous injection for 4 weeks. After induction of osteoporosis, rats in group III were fed with BD supplemented with 7% flaxseeds daily for 8 weeks. After 12 weeks, rats were euthanized. The mandible was dissected and prepared for scanning electron microscope (SEM) and energy dispersive x-ray microanalysis (EDX).
RESULTS: It was found that the alveolar bone in the control group had normal ultrastructural traits. There were alterations to the ultrastructure of the cortical bone surface in the glucocorticoid group. The trabecular bone also had wide marrow spaces and poorly developed trabeculae. Compared to group II, group III had a more regular cortical bone surface with well architecture trabeculae and narrow marrow spaces.
CONCLUSION: Flaxseeds is suggested as a therapeutic approach for alveolar bone osteoporosis.
Keywords
Flaxseeds; glucocorticoids; osteoporosis; alveolar bone
Main Subjects
Oral biology
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