Home Articles List Article Information
Alexandria Dental Journal
Journal Archive
Volume Volume 50 (2025)
Volume Volume 49 (2024)
Volume Volume 48 (2023)
Volume Volume 47 (2022)
Volume Volume 46 (2021)
Volume Volume 45 (2020)
Volume Volume 44 (2019)
Volume Volume 43 (2018)
Volume Volume 42 (2017)
Volume Volume 41 (2016)
Volume Volume 40 (2015)
Shamma, M., Ayad, S., El-dibany, R., Nagui, D. (2017). EVALUATION OF THE EFFECT OF HYALURONIC ACID MIXED WITH BIPHASIC CALCIUM PHOSPHATE ON BONE HEALING AROUND DENTAL IMPLANTS (EXPERIMENTAL STUDY). Alexandria Dental Journal, 42(1), 104-107. doi: 10.21608/adjalexu.2017.57868
Mostafa M. Shamma; Sherif S. Ayad; Riham M. El-dibany; Dina A. Nagui. "EVALUATION OF THE EFFECT OF HYALURONIC ACID MIXED WITH BIPHASIC CALCIUM PHOSPHATE ON BONE HEALING AROUND DENTAL IMPLANTS (EXPERIMENTAL STUDY)". Alexandria Dental Journal, 42, 1, 2017, 104-107. doi: 10.21608/adjalexu.2017.57868
Shamma, M., Ayad, S., El-dibany, R., Nagui, D. (2017). 'EVALUATION OF THE EFFECT OF HYALURONIC ACID MIXED WITH BIPHASIC CALCIUM PHOSPHATE ON BONE HEALING AROUND DENTAL IMPLANTS (EXPERIMENTAL STUDY)', Alexandria Dental Journal, 42(1), pp. 104-107. doi: 10.21608/adjalexu.2017.57868
Shamma, M., Ayad, S., El-dibany, R., Nagui, D. EVALUATION OF THE EFFECT OF HYALURONIC ACID MIXED WITH BIPHASIC CALCIUM PHOSPHATE ON BONE HEALING AROUND DENTAL IMPLANTS (EXPERIMENTAL STUDY). Alexandria Dental Journal, 2017; 42(1): 104-107. doi: 10.21608/adjalexu.2017.57868

EVALUATION OF THE EFFECT OF HYALURONIC ACID MIXED WITH BIPHASIC CALCIUM PHOSPHATE ON BONE HEALING AROUND DENTAL IMPLANTS (EXPERIMENTAL STUDY)

Article 17, Volume 42, Issue 1, April 2017, Page 104-107  XML PDF (919.39 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2017.57868
View on SCiNiTO View on SCiNiTO
Authors
Mostafa M. Shamma* 1; Sherif S. Ayad2; Riham M. El-dibany2; Dina A. Nagui3
1B. D. S. Faculty of Dentistry, Alexandria University
2Professor of Oral & Maxillofacial Surgery, Faculty of Dentistry, Alexandria University
3Lecturer of Oral Biology, Faculty of Dentistry, Alexandria University.
Abstract
INTRODUCTION: Biphasic calcium phosphate (BCP) is very widely used as a grafting material around dental implants. The properties of such material can be enhanced by adding interpositional graft materials to enhance osteoinduction. Hyaluronic acid (HyA) is an example of osteopromoting materials that can be added to the BCP to enhance its osteoinductive properties. OBJECTIVES: Histological evaluation of using HyA with BCP on bone healing around dental implants. MATERIALS AND METHODS: This study was a split mouth design. It was conducted on 9 mongrel dogs. The dogs were allocated into two groups: Group A (Study Group): The right side of the mandible received dental implants with biphasic calcium phosphate bone graft mixed with hyaluronic acid following extraction of the mandibular third premolar. Group B (Control Group): The left side of the mandible received dental implants with biphasic calcium phosphate bone graft only following extraction of the mandibular third premolar. Dogs were sacrificed at 2, 4 and 6 weeks postoperatively. Segments containing the implant and bone graft were retrieved with adjacent bone to be prepared for histological examination using Haematoxylin and eosin stain and Trichrome stain. RESULTS: All animals survived well, and remained active and alert all over the course of the experiment. Both groups were characterized by new bone formation. The newly formed bone was more evident in association with group (A). CONCLUSIONS: HyA accelerates the onset of new bone formation when combined with BCP for bone augmentation in the treatment of osseous defects.
Keywords
Dental implants; Biphasic Calcium phosphate; Mandible; Hyaluronic acid; osseointegration
Main Subjects
Oral and maxillofacial surgery
References
1. Bain C, Moy P. The association between the failure of dental implants and cigarette smoking. Int J Oral Maxillofac surg. 1993; 8: 609-15. 

2. Puleo D, Thomas M. Implant surfaces. Dent Clin North Am. 2006; 50: 323-38. 
3. David A, Mark V. Implant Surfaces. Dent Clin N Am. 2006; 50: 323–38. 
4. Cooper L.F, Rahman A, Moriarty J, Chaffee N, Sacco D. Immediate mandibular rehabilitation with endosseous implants: Simultaneous extraction, implant placement and loading. Int J Oral Maxillofac surg. 2002; 17(4), 517-25. 
5. Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S. Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1989; 4: 19–25. 
6. Tamini F, Torres J, Tresguerres I, Clemente C, Cabarcos E. Bone augmentation in rabbit calavaria: comparative study between Bio-Oss and a novel B-TCP/DCPD granulate J Clin Periodontol. 2006; 33: 922-8. 
7. Fraser RE, Laurent TC, Laurent BG. Hyaluronan: Its Nature, Distribution, Functions and Turnover. J Intern Med 1997; 242: 27–33. 
8. Stecco C, Stern R, Porzionato A, Macchi V, Masiero S, Stecco A, De Caro R. Hyaluronan within fascia in the etiology of myofascial pain. Surg Radiol Anat. 2011; 33(10): 891–6. 
9. Tan H, Li H, Rubin J, Marra K. Controlled gelation and degradation rates of injectable hyaluronic acid based hydrogels through a double crosslinking strategy. J regen Med. 2011; 5(10): 790–7. 
10. Zhao N, Wang X, Qin L. Effect of molecular weight and concentration of hyaluronan on cell proliferation and osteogenic differentiation in vitro. Biochem phys Res. 2015; 465(3): 569-74. 
11. Bolukbsi N, Yeniyol S, Soluk M, Altunatmaz K. The use of platelet rich fibrin in combination with biphasic calcium phosphate in the treatment of bony defects: a histologic and histomorphometric study. Curr Therap Res. 2013; 75: 15- 21. 
12. Daculsi G, LeGeros R. Encyclopedia of biomaterials and biomedical engineering, 2nd ed. New York: Informa Healthcare Inc. 2006; 359-66. 
13. Manjubala I, Sastry T, Kumar R. Bone ingrowth induced by biphasic calcium phosphate ceramic in femoral defect of dogs. J Biomater Apppl. 2005; 19: 341-60. 
14. West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science 1985; 228: 1324–6. 
15. King S, Hickerson W, Proctor K, Newsome A. Benefical Actions of Exogenous Hyaluronic Acid on Wound Healing. Surgery. 1991; 109(1): 76–84. 
16. Aslan M, Simsek G, Dayi E. The effect of hyaluronic acid supplemented bone graft in bone healing: experimental study in rabbits. J Biomater Appl 2006; 20: 209-20. 
17. Stern M, Schmidt B, Dodson TB, Stern R, Kaban LB. Fetal cleft lip repair in rabbits: histology and role of hyaluronic acid. J Oral Maxillofac Surg 1992; 50: 263–9. 
18. Kim JJ, Song HY, Ben Amara H, Kyung-Rim K, Koo KT. Hyaluronic Acid Improves Bone Formation in Extraction Sockets with Chronic Pathology: A Pilot Study in Dogs. J Periodontol. 2016; 87(7): 790-5. 
19. Aguado E, Florence P, Christine G, Eric G, Daniel C. βTCP granules mixed with reticulated hyaluronic acid induces an increase in bone apposition. Biomed Mater. 2013; 9(1): 015001.
Statistics
Article View: 486
PDF Download: 1,103