Abdelaziz, M., Shaaban, R., Abdelhalim, S., Sadaka, M. (2015). EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY). Alexandria Dental Journal, 40(2), 166-172. doi: 10.21608/adjalexu.2015.59145
M Abdelaziz; R Shaaban; S Abdelhalim; M Sadaka. "EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY)". Alexandria Dental Journal, 40, 2, 2015, 166-172. doi: 10.21608/adjalexu.2015.59145
Abdelaziz, M., Shaaban, R., Abdelhalim, S., Sadaka, M. (2015). 'EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY)', Alexandria Dental Journal, 40(2), pp. 166-172. doi: 10.21608/adjalexu.2015.59145
Abdelaziz, M., Shaaban, R., Abdelhalim, S., Sadaka, M. EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY). Alexandria Dental Journal, 2015; 40(2): 166-172. doi: 10.21608/adjalexu.2015.59145
EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY)
Resident in Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University.
Abstract
Introduction: Dentists perform a variety of surgical procedures frequently requiring the need for a hemostatic agent, in cases where oral anticoagulants are used. Most cases of postoperative bleeding are easily treated with local measures such as packing with a haemostatic dressing, suturing and pressure. Objectives: We aimed to evaluate the efficacy of Collaplug® in minimizing postoperative bleeding and pain following tooth extraction in patients under oral anticoagulant therapy. Materials and methods: A prospective study was conducted on a total of 40 adult patients under oral anticoagulant therapy, who needed tooth extraction. Patients were divided equally into two groups, each group consisting of 20 patients. Group A (Study group): the extraction of the tooth was followed by the application of Collaplug® prior to suturing of the socket. Group B (Control group): the extraction of the tooth was followed by suturing only. Results: A total of 40 patients 21 female (52%) and 19 (48%) male, aged between 30 and 60 years were included in the present study. All patients underwent simple tooth extraction. In the study group: there was a clinical significance in cessation of bleeding 2 hours and 6 hours after extraction than the control group. All patients of study and control groups had their international normalized ratio (INR)Conclusion: The study concluded that Collaplug® is an effective local hemostatic material following minor oral surgery in patients under oral anticoagulant therapy, also shows acceleration of soft tissue healing and reduce postoperative pain.
1. Dagi TF. The management of postoperative bleeding. Surg Clin North Am 2005; 85: 1191–213.
2. Spencer FA, Moscucci M, Granger CB, Gore JM, Goldberg RJ, Steg PG, et al. Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction? Circulation 2007; 116: 2793–801.
3. Beirne OR. Evidence to continue oral anticoagulant therapy for ambulatory oral surgery. J Oral Maxillofac Surg 2005; 63: 540-5
4. Aframian, DJ, Lalla RV, Peterson DE. Management of dental patients taking common hemostasis-altering medications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103 Suppl:S45–S11.
5. Karsli ED, Erdogan O, Esen E, Acarturk E. Comparison of the effects of warfarin and heparin on bleeding caused by dental extraction: a clinical study. J Oral Maxillofac Surg. 2011;69:2500–2507.
6. Salam S, Yusuf H, Milosevic A. Bleeding after dental extractions in patients taking warfarin. Br J Oral Maxillofac Surg. 2007;45: 463–466.
7. Abdullah WA, Khalil H. Dental extraction in patients on warfarin treatment. Clin Cosmet Investig Dent 2014; 6: 65-9.
8. Nematullah A, Alabousi A, Blanas N, Douketis JD, Sutherland SE. Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis. Tex Dent J 2009; 126: 1183– 93.
9. Randall C. Surgical management of the primary care dental patient on warfarin. Dent Update 2005; 32: 414– 20.
11. Scully C, Cawson RA. Medical problems in dentistry. 4th ed. Oxford, London, Boston: Wright, ButterworthHeinemann, 1997.
12. Little JW, Falace DA, Miller CS, Rhodus NL. Dental management of the medically compromised patient. 5th ed. St Louis: CV Mosby Co, 1997.
13. Blinder D, Manor Y, Martinowitz U, Taicher S, Hashomer T. Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88: 137-40.
14. Schardt-Sacco D. Update on coagulopathies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 90:559-63
16. McBee WL, Koerner KR. Review of hemostatic agents used in dentistry. Dent Today 2005; 24: 62-5.
17. Schonauer C, Tessitore E, Barbagallo G, Albanese V, Moraci A. The use of local agents: bone wax, gelatin, collagen, oxidized cellulose. Eur Spine J 2004; 13: 89–96.
18. Mahesh L, Kurtzman GM2, Shukla S. Regeneration in Periodontics: Collagen-A Review of Its Properties and Applications in Dentistry. Compend Contin Educ Dent 2015; 36: 358-63.
19. Sclar AG. Strategies for management of single-tooth extraction sites in aesthetic implant therapy. J Oral Maxillofac Surg 2005; 62: 90-105.
20. Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981; 47: 207-14.
21. Pain Rating Scale. British pain Society, 2007. Available at: http://www.britishpainsociety.org/pain _scales_eng.pdf
22. De Caterina R, Lanza M, Manca G, Strata GB, Maffei S, Salvatore L. Bleeding Time and Bleeding: An analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood J 1994; 84: 3363-70.
23. Gewirtz AS, Miller ML, Keys TF. The clinical usefulness of the preoperative bleeding time. Arch Pathol Lab Med 1996; 120: 353-6.
24. Lind SE. The Bleeding time does not predict surgical bleeding. Blood 1991; 77: 2547-52.
25. Lehman CM. Discontinuation of BT without detectable adverse clinical impact. Clin Chem 2001; 47: 1204-11.
26. Hirsh J, Dalen J, Anderson DR, Poller L, Bussey H, Ansell J, et al. Oral anticoagulants: Mechanism of action, clinical effectiveness and optimal therapeutic range. Chest 2001; 119: 8-21.
27. Svensson R, Hallmer F, Englesson CS, Svensson PJ, Becktor JP. Treatment with local hemostatic agents and primary closure after tooth extraction in warfarin treated patients. Swed Dent J 2013; 37: 71-7.
28. Blinder D, Manor Y, Martinowitz U, Taicher S. Dental extractions in patients maintained on oral anticoagulant therapy:. Comparison of INR value with occurrence of postoperative bleeding. Int J Oral Maxillofac Surg 2001; 6: 518-21.
29. Suleiman AM. Influence of Surgicel gauze on the incidence of dry socket after wisdom tooth extraction. East Mediterr Health J 2006; 12: 440-5.
30. Mattsson T, Anneroth G, Köndell PA, Nordenram A. ACP and Surgicel in bone hemostasis. A comparative experimental and histologic study. Swed Dent J 1990; 14: 57-62.
31. Matthew IR, Browne RM, Frame JW, Millar BG. Subperiosteal behaviour of alginate and cellulose wound dressing materials. Biomaterials 1995; 16: 275–8.
32. Peterson P, Hayes TE, Arkin CF, Bovill EG, Fairweather RB, Rock WA Jr, et al. The Preoperative Bleeding Time Test Lacks Clinical Benefit; College of American Pathologists' and American Society of Clinical Pathologists' Position Article. Arch Surg 1998; 133: 134-9.
View on SCiNiTO
Top